prof. Jo Vandesompele (PhD)

CRIG group leader
Jo Vandesompele
  • Principal investigator - Lab for functional cancer genomics and applied bioinformatics, Center for Medical Genetics (UGent)
  • Full professor (Faculty of Medicine and Health Sciences, UGent)
  • Co-founder of CRIG, Chairman of the CRIG steering committee
  • Partner (Bioinformatics Institute Ghent)
  • Co-founder and Chief Scientific Officer (Biogazelle)

Research focus



Jo Vandesompele obtained a Master of Science in Bioscience Engineering (1997) and a PhD in Medical Genetics (2002). Since 2007, he is professor in Functional Cancer Genomics and Applied Bioinformatics at Ghent University and co-founder and Chief Scientific Officer at Biogazelle. He is author of more than 200 scientific articles in international journals, including some pioneering publications in the domain of nucleic acid quantification. His H-index is 74, with over 42,000 citations (Google Scholar, May 2018). Jo Vandesompele is member of the cancer expertpanel (Research Fund Flanders - FWO) and frequently invited speaker at international conferences and workshops.

Research team

Key publications

  • Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma. Journal of Clinical Oncology, 2005
  • Antitumor activity of the selective MDM2 antagonist nutlin-3 in a chemoresistant model of neuroblastoma. Journal of the Nat Cancer Institute, 2009
  • Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study. Lancet Oncology, 2009 
  • The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma. Molecular Cell, 2010 
  • miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples. Clinical Cancer Research, 2011 
  • Melanoma addiction to the long noncoding RNA SAMMSON. Nature, 2016

Contact & links