prof. Bart Vandekerckhove (MD, PhD)

CRIG group leader
Bart Vandekerckhove

Director of GMP Unit Cell therapy, Cord blood Bank and Hematopoietic Stem cell Bank, UZ Gent
Professor Department of Clinical Chemistry, microbiology and immunology

 

Research focus

  • Generation of effective CAR/TCR transgenic T cells
  • Acquisition of function by T cell precursors
  • Development of in vitro or animal models for human T cell maturation
  • Enabling phase I trials with cell and gene therapy medicinal products
     

Research team

  • dr. Rupert Mayer (PhD)  - post-doctoral fellow
  • dr Karen Weening -post-doctoral fellow
  • Stijn De Munter - doctoral fellow
  • Joline Ingels - doctoral fellow
  • Laurenz De Cock - doctoral fellow
  • Melissa Pille - doctoral fellow
  • Glenn  Goetgeluk - technician
  • Pam Devreker-technician
  • Saskia De Smedt-technician
     

Key publications

  • De Munter S, Ingels J, Goetgeluk G, Bonte S, Pille M, Weening K, Kerre T, Abken H, Vandekerckhove B, Nanobody Based Dual Specific CARs.  Int J Mol Sci. 2018 Jan 30;19(2). pii: E403. doi: 10.3390/ijms19020403. PubMed PMID: 29385713.
  • Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B, The checkpoint for agonist selection precedes conventional selection in human thymus. Sci Immunol. 2017 Feb  24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232. PubMed PMID: 28783686; PubMed Central PMCID: PMC5569900.
  • Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G,  Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H, Vandekerckhove B, Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.  Oncoimmunology. 2017 Jan 19;6(3):e1283460. doi: 10.1080/2162402X.2017.1283460. eCollection 2017. PubMed PMID: 28405508; PubMed Central PMCID: PMC5384408.
  • In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection, Leukemia. 2014 PubMed PMID: 24091848.
  • RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia, Haematologica. 2012 PubMed PMID: 22532518;PubMed Central PMCID: PMC3487554.
  • Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway, Leukemia. 2012 PubMed PMID: 22051534.
     

Contact & links

  • UZ Gent, MRB2, ingang 38, C Heymanslaan 10, 9000 Gent