prof. Bart Vandekerckhove (MD, PhD)
CRIG group leader
Director of GMP Unit Cell therapy, Cord blood Bank and Hematopoietic Stem cell Bank, UZ Gent
Professor Department of Clinical Chemistry, microbiology and immunology
Research focus
- Generation of effective CAR/TCR transgenic T cells
- Acquisition of function by T cell precursors
- Development of in vitro or animal models for human T cell maturation
- Enabling phase I trials with cell and gene therapy medicinal products
Research team
- dr Karen Weening - post-doctoral fellow
- Stijn De Munter - doctoral fellow
- Joline Ingels - doctoral fellow
- Laurenz De Cock - doctoral fellow
- Melissa Pille - doctoral fellow
- Hanne Jansen - doctoral fellow
- Lore Billiet - doctoral fellow
- Eva Pascal - doctoral fellow
- Killian Raes - doctoral fellow
- dr. Lucas Deseins (MD) - doctoral fellow
- Glenn Goetgeluk - technician
- Saskia De Smet - technician
Key publications
- Tieppo P, Papadopoulou M, Gatti D, McGovern N, Chan JKY, Gosselin F,Goetgeluk G, Weening K, Ma L, Dauby N, Cogan A, Donner C, Ginhoux F,Vandekerckhove B, Vermijlen D. The human fetal thymus generates invariant effector γδ T cells. J Exp Med. 2020 Mar 2;217(3):e20190580. doi:10.1084/jem.20190580. PMID: 31816633.
- Huyghe L, Van Parys A, Cauwels A, Van Lint S, De Munter S, Bultinck J, Zabeau L, Hostens J, Goethals A, Vanderroost N, Verhee A, Uzé G, Kley N, Peelman F, Vandekerckhove B, Brouckaert P, Tavernier J. Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies. EMBO Mol Med. 2020 Feb 7;12(2):e11223. doi: 10.15252/emmm.201911223. Epub 2020 Jan 8. PMID: 31912630.
- De Munter S, Ingels J, Goetgeluk G, Bonte S, Pille M, Weening K, Kerre T, Abken H, Vandekerckhove B, Nanobody Based Dual Specific CARs. Int J Mol Sci. 2018 Jan 30;19(2). pii: E403. doi: 10.3390/ijms19020403. PubMed PMID: 29385713.
- Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B, The checkpoint for agonist selection precedes conventional selection in human thymus. Sci Immunol. 2017 Feb 24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232. PubMed PMID: 28783686; PubMed Central PMCID: PMC5569900.
- Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H, Vandekerckhove B, Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology. 2017 Jan 19;6(3):e1283460. doi: 10.1080/2162402X.2017.1283460. eCollection 2017. PubMed PMID: 28405508; PubMed Central PMCID: PMC5384408.
- In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection, Leukemia. 2014 PubMed PMID: 24091848.
Contact & links
- UZ Gent, MRB2, ingang 38, C Heymanslaan 10, 9000 Gent