prof. Bart Vandekerckhove (MD, PhD)
CRIG group leader
![Bart Vandekerckhove](/sites/default/files/styles/partner_desktop/public/media/image/bartvandekerckhove2.jpg?h=b0903704&itok=grGbYls-)
Director of GMP Unit Cell therapy (CellGENTherapies), Cord blood Bank and Hematopoietic Stem cell Bank, UZ Gent
Professor Department of Clinical Chemistry, microbiology and immunology
Research focus
- Generation of effective CAR/TCR transgenic T cells
- Enabling phase I trials with cell and gene therapy medicinal products
- Neoepitope discovery in human cancer
- RNA vaccines and ATMPs
Research team
- Postdoctoral fellows
- dr. Stijn De Munter (PhD)
- Doctoral fellows
- Laurenz De Cock
- Lore Billiet
- Eva Pascal
- dr. Lucas Deseins (MD)
- Amin Zolfaghari
- Thomas Michiels
- dr. Robrecht De Vos (MD)
- Glenn Goetgeluk - technician
- GMP unit
- Louise De la Mane, QP pharmacist
- Valerie Redant, PhD
- Joline Ingels,Ms
- Bo Coppens, GMP technician
- Sofie Leyman, GMP technician
- Saskia De Smet, GMP technician
- Nele Lootens, Quality assurance
Key publications
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage. J Exp Med. 2023 Jun 5;220(6):e20220942. doi: 10.1084/jem.20220942. Epub 2023 Mar 20. PMID: 36939517; PMCID: PMC10037106.
- Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials. Cytotherapy. 2022 Feb;24(2):213-222. doi: 10.1016/j.jcyt.2021.08.005. Epub 2021 Oct 22. PMID: 34696961.
- The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation. Blood. 2020 Jul 16;136(3):288-298. doi: 10.1182/blood.2020005204. PMID: 32350509.
- Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly. Int J Mol Sci. 2020 Jan 30;21(3):883. doi: 10.3390/ijms21030883. PMID: 32019116; PMCID: PMC7037261.
- Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies. EMBO Mol Med. 2020 Feb 7;12(2):e11223. doi: 10.15252/emmm.201911223. Epub 2020 Jan 8. PMID: 31912630; PMCID: PMC7709889.
- The human fetal thymus generates invariant effector γδ T cells. J Exp Med. 2020 Mar 2;217(3):jem.20190580. doi: 0.1084/jem.20190580. PMID: 31816633; PMCID: PMC7062527.
Contact & links
- UZ Gent, MRB2, ingang 38, C Heymanslaan 10, 9000 Gent
- website of CellGENTherapies (GMP unit)