prof. Bart Vandekerckhove (MD, PhD)

CRIG group leader
Bart Vandekerckhove

Director of GMP Unit Cell therapy, Cord blood Bank and Hematopoietic Stem cell Bank, UZ Gent
Professor Department of Clinical Chemistry, microbiology and immunology

 

Research focus

Generation of CAR/TCR transgenic T cell with single receptor. These T cells express only the transgenic receptor and no other endogenous receptors which may cause GvHD in an allogeneic setting.
Vaccins against mutanome in cancer patient

Research team

Key publications

  • De Munter S, Ingels J, Goetgeluk G, Bonte S, Pille M, Weening K, Kerre T, Abken H, Vandekerckhove B, Nanobody Based Dual Specific CARs.  Int J Mol Sci. 2018 Jan 30;19(2). pii: E403. doi: 10.3390/ijms19020403. PubMed PMID: 29385713.
  • Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B, The checkpoint for agonist selection precedes conventional selection in human thymus. Sci Immunol. 2017 Feb  24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232. PubMed PMID: 28783686; PubMed Central PMCID: PMC5569900.
  • Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G,  Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H, Vandekerckhove B, Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.  Oncoimmunology. 2017 Jan 19;6(3):e1283460. doi: 10.1080/2162402X.2017.1283460. eCollection 2017. PubMed PMID: 28405508; PubMed Central PMCID: PMC5384408.
  • In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection, Leukemia. 2014 PubMed PMID: 24091848.
  • RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia, Haematologica. 2012 PubMed PMID: 22532518;PubMed Central PMCID: PMC3487554.
  • Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway, Leukemia. 2012 PubMed PMID: 22051534.

Contact & links

  • MRB 2, UZ Gent