prof. Tom Taghon (PhD)

CRIG group leader
Tom Taghon

Full Professor (Faculty of Medicine and Health Sciences, Ugent)
 

Research focus

The overall goal of our work is to understand the transcriptional network that induces and controls T cell development in human. T lymphocytes are vital cells of the immune system and comprise a particular type of blood cells that is generated from the blood forming hematopoietic stem cells. In clinical settings where hematopoietic stem cells are transplanted to rebuild the immune system, for instance following chemotherapy with the aim to eradicate cancer cells, the recovery of T lymphocytes is slow and often limited, leading to a prolonged phase of immune deficiency in which patients are highly susceptible to infections. By obtaining novel insights into the molecular network that induces the step-wise conversing of hematopoietic stem cells into T lymphocytes, we aim to improve the development of these immune cells following stem cell transplantation. In addition, since many of the key transcriptional regulators of normal T lymphocyte development are often aberrantly expressed in T-acute lymphoblastic leukemia, another part of our work aims to reveal how gain- or loss-of-function expression of these factors alters normal T cell development and contributes to oncogenic transformation. By studying the changes in gene expression that occur upon such perturbations, these insights provide novel opportunities for targeted therapy.

Biography

  • Master in Biotechnology (1997, Ghent University)
  • PhD in Medical Sciences (2002, lab of Dr. Georges Leclercq and Dr. Jean Plum, Ghent University)
  • Postdoc at California Institute of Technology (US, lab of Dr. Ellen Rothenberg)
  • Odysseus II Grant (2007)
  • Award of the Royal Academy of Medical Sciences Belgium for fundamental medical research (2009)
  • Associate Professor (2012)
  • ANR committee member
  • Review Editor for Frontiers in Immunology   
  • FWO expert panel member

Research team

  • prof. Tom Taghon - principal investigator, associate professor
  • dr. Kai Ling Liang (PhD) - post-doctoral fellow
  • dr. Anna Kuchmiy(MD, PhD) - post-doctoral researcher 
  • Anne-Catherine Dolens - doctoral fellow
  • Steven Strubbe - doctoral fellow
  • Matthias De Decker - doctoral fellow
  • Marieke Lavaert - doctoral fellow
  • Juliette Roels - doctoral fellow
  • dr. Tamara De Vos (MD) - doctoral fellow
  • Nina Lambrechts - doctoral fellow
  • Imke Velghe - Technician

Key publications

  • Roger A. Habets, Charles E. de Bock, Lutgarde Serneels, Inge Lodewijkx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools, Bart de Strooper; Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition; Science Translational Medicine 2019 11:494
  • Goossens S, Wang J, Tremblay C, De Medts J, T'Sas S, Nguyen T, Saw J, Haigh K, Curtis DJ, Van Vlierberghe P, Berx G, Taghon T, Haigh JJ.; ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms. ; Haematologica. 2019 104:1608
  • Stéphanie Gachet, Tiama El-Chaar, David Avran, Eulalia Genesca, Frédéric Catez, Samuel Quentin, Marc Delord, Gabriel Thérizols, Delphine Briot, Godelieve Meunier, Lucie Hernandez, Marika Pla, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Wouter Van Loocke, Gerben Menschaert, Isabelle André-Schmutz, Tom Taghon, Pieter Van Vlierberghe, Jules P. Meijerink, André Baruchel, Hervé Dombret, Emmanuelle Clappier, Jean-Jacques Diaz, Claude Gazin, Hugues de Thé, François Sigaux, and Jean Soulier; Deletion 6q drives T-cell leukemia progression by ribosome modulation.;Cancer Discov. 2018 12:1614
  • 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network'. Nucleic Acids Research, 2016 (PMID: 27604872)
  • 'Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia'. Leukemia, 2016 (PMID: 27168467)
  • 'The European Hematology Association Roadmap for European Hematology Research: a consensus document'. Haematologica, 2016 (PMID: 26819058)
  • 'ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling'. Nature Communications, 2015. (PMID: 25565005)
  • 'The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia'. Blood, 2015 (PMID: 25320243)
  • 'The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia'. Haematologica, 2014. (PMID: 25344525)
  • 'A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)'. Nature Genetics, 2011. (PMID: 21642990)
  • 'A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia'., Nature, 2011 (PMID: 21562564)
  • 'PHF6 mutations in T-cell acute lymphoblastic leukemia'. Nature Genetics, 2010 (PMID: 20228800)

Contact & links