dr. Nicole Oatman (PhD)
Postdoctoral researcher – Faculty of Medicine and Health Sciences, Prof. Tom Taghon’s group, UGent.
Principal investigator: prof. Tom Taghon (PhD)
Research focus
Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer. It is a highly heterogeneous malignant hematological disorder that is driven by recurrent genetic abnormalities. Hence, the molecular genetic makeup of ALL influences treatment strategies and dictates risk stratification. GATA3 is a T-cell lineage transcription factor whose expression is tightly regulated during normal development of lymphoid progenitors.
We discovered that significant elevated expression of GATA3 is a distinct feature of a subset of ALL cases that harbor fusion oncogenes. We hypothesize that aberrant expression of GATA3 is a unifying secondary genetic lesion in the pathogenesis of these ALL subsets that have different clinical and biological characteristics. Hence, we aim to gain a deeper understanding of the role of GATA3 misexpression across these subsets. Ultimately, we hope this will improve the current classification of ALL and uncover potential therapeutic targets.
Key publications
- A Multimodal-Drug-Diet-Immunotherapy Combination Restrains Melanoma Progression and Metastasis. Cancer Research, 2024. (PMID: 38885087)
- HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells. Haematologica, 2024. (PMID: 38572564)
- Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances, 2021. (PMID: 33568479)
- AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Cell Reports, 2020. (PMID: 32877674)
- The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro-Oncology, 2017. (PMID: 28339768)
- Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer. Genome Integrity, 2012. (PMID: 22494821)
Contact & links
- Lab address: Corneel Heymanslaan 10, ingang 38, MRB2, 9000 Gent
- Nicole Oatman is interested to receive invitations for presentations or talks