prof. Sylvie Rottey (MD, PhD)

CRIG group leader
Sylvie Rottey


Head of Department of Medical Oncology
Head of the Drug Research Unit Ghent - especially performing phase I trials first in humans - healthy volunteers and cancer patients
Medical Oncologist
MD Specialist in Clinical Pharmacology and Pharmaceutical Medicine 
UGent : Department of Fundamental and Applied Medical Science GE33
Member of recognition committee and Internships for Clinical Pharmacology/Pharmaceutical Medicine - UGent 
 

Research focus

For the last twenty years, prof. dr. Rottey is involved in international high-level research towards novel therapeutic options for patients with various solid tumors As prof. dr. Rottey is leading phase I oncology clinical trials for more than a decade, she has worked and continues to work with different immunotherapies in development, antibody drug conjugates, T-cell therapies, biomarker based treatments,… .

Prof. dr. Rottey is promotor for the doctorate of:

  • dr. Alexander Decruyenaere (MD) – co-investigator, doctoral fellow, 2022 - ongoing: 'The Real Deal Behind the Artificial Appeal: Inferential Utility of Tabulator Synthetic Data'
  • dr. Daan De Maeseneer (MD) – co-investigator, doctoral fellow, 2020 – ongoing: 'Evaluating bladder cancer genetics as predictive and prognostic biomarkers'
  • Lissa Eggermont – doctoral fellow, 2023 – ongoing: 'Urine N-glycosylation as biomarker for prostate cancer: optimalisation of preanalytic conditions and correlation to clinical parameters in the differential diagnosis of prostate cancer'
  • dr. Michael Saerens (MD) – co-investigator, doctoral fellow, 2022 – ongoing: 'Tumor-associated macrophages in head and neck squamous cell carcinoma: association with CD8+ tumor-infiltrating T-lymphocytes and impact on survival'
  • Li Shoabo – doctoral fellow, 2024 – ongoing: 'SSTR-2 expression on tumor-associated macrophages in solid malignancies – predictive and prognostic value in patients receiving immune-checkpoint inhibitors'
  • Mathieu Spaas – doctoral fellow, 2020 – ongoing: 'Checkpoint inhibitors in combination with stereotactic body radiotherapy in patients with advanced solid tumours'
  • dr. Eufra Van Damme (MD) - doctoral fellow, 2021 – ongoing: 'Prediction of immunotherapy response and toxicity in melanoma, renal cell and lung cancer using transcriptome based systemic immune phenotyping'
     

Biography

  • Medical doctor, Ghent University, 1993-2000
  • Board certificate of internal medicine, 2002
  • Medical Oncology, 2003
  • PhD: Doctor in Medical Science, 99mTc-HYNIC Annexin-V for monitoring response to chemotherapy: methodology and feasibility studies, 2007
  • Professor in Pharmacology, 2011
  • Head of Drug Research Unit Ghent , 2015
  • Head of Department of Medical Oncology, 2000
  • MD in  clinical pharmacology and pharmaceutical medicine, 2024
     

Research team

  • prof. Sylvie Rottey (MD, PhD) – principal investigator
     
  • Team members of the medical staff department of Medical Oncology:
    •    dr. Alexander Decruyenaere (MD) – co-investigator, doctoral fellow
    •    prof. Hannelore Denys (MD, PhD) – principal investigator, co-investigator
    •    dr. Daan De Maeseneer (MD) – co-investigator, doctoral fellow
    •    dr. Elien De Mulder (MD) – co-investigator
    •    dr. Aglaja De Pauw (MD) – co-investigator
    •    dr. Ingeborg Hilderson (MD) – co-investigator
    •    dr. Justine Himpe (MD) – co-investigator
    •    dr. Celine Jacobs (MD) – principal investigator, co-investigator
    •    prof. Lore Lapeire (MD, PhD) – principal investigator, co-investigator
    •    dr. Eline Naert (MD) – principal investigator, co-investigator, doctoral fellow
    •    dr. Michael Saerens (MD) – principal investigator, co-investigator, doctoral fellow
    •    dr. Tijl Vermassen (PhD) – post-doctoral researcher
     
  • Team D.R.U.G, investigators:
    •    dr. Brant Delafontaine (MD) – co-investigator 
    •    dr. Greet Schelfaut (MD) – co-investigator
    •    dr. Griet Van Lancker (MD) – co-investigator
    •    dr. Jasper Vogels (MD) – co-investigator
     
  • Team D.R.U.G, teamlead:
    •    Elke Colman, teamlead Safepedrug Clinical Trial Unit
    •    Katrijn Criel, teamlead Drug Research Unit Ghent
    •    Adelheid Hollebosch, teamlead Drug Research Unit Ghent
    •    Carla Vandenabeele, teamlead Drug Research Unit Ghent
     

Key publications

Find all publications of prof. Rottey via Ghent University Academic Bibliography or PubMed
 

Contact