dr. Mohammad Rahimi Gorji (PhD)

CRIG member
Mohammad Rahimi Gorji


FWO Postdoctoral Researcher
- Experimental Surgery Lab, Faculty of Medicine and Health Sciences, UGent.
- IBiTech-BioMMedA, Faculty of engineering and architecture, UGent
Principal investigators: prof. Wim Ceelen (MD, PhD) and prof. Charlotte Debbaut (PhD)
 

Research focus

Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) has emerged as a novel approach for delivering chemotherapy drugs intraperitoneally to treat patients with peritoneal metastasis. This technique involves introducing a nebulizer into the peritoneal cavity during laparoscopy. My research focuses on several key areas:

  • Developing a coupled in vitro and computational model based on a realistic 3D geometry of the human peritoneal cavity.
  • Investigating aerosol droplet–tissue interactions using high-speed macro-imaging combined with analytical techniques.
  • Optimizing an additional electrostatic precipitation during PIPAC, leading to the development of ePIPAC.
  • Studying tissue penetration of aerosolized droplets.
  • Exploring novel methods for nebulizing viscous agents or hydrogels for aerosolized drug delivery.
  • Developing a large animal model (pig) for (e)PIPAC.

Additionally, I am working on intraperitoneal drug delivery using a branched catheter. The goal of this project is to develop an innovative multi-arm catheter for intraperitoneal drug delivery to treat patients with peritoneal metastases. This catheter is designed to enhance spatial drug distribution, enable prolonged low-dose chemotherapy administration, and eliminate the need for large-volume intraperitoneal instillations. A combined computational and experimental approach is used to optimize this drug delivery technique.

 

Contact & links

  • Lab address: campus UZ Gent, C. Heymanslaan 10,
    - Experimental Surgery Lab: The Core, ingang 37, verdieping 3
    - Lab address: IBiTech-BioMMedA, Department of Electronics and Information Systems (Ghent University), The Core, ingang 37
  • Mohammad Rahimi Gorji is interested to receive invitations for presentations or talks