prof. Anne Vral (PhD)

CRIG group leader
Anne Vral

Principal investigator radiobiology group
Associate professor (Faculty of Medicine and Health Sciences, UGent) 

Research focus

The main focus of the research team is in in the field of basic and medically applied (radiation diagnostics and radiotherapy) radiobiology, radiation protection, biological dosimetry and cancer. The topics related to cancer are dealing with radiosensitivity, the underlying DNA double strand break repair mechanisms (homologous recombination and non-homologous end-joining) and the link with cancer predisposition esp. breast cancer (BRCA1&2). The expertise covers a broad range of technologies used to study effects of radiation such as cytogenetic assays (microcnucleus assay, dicentric assay), cell culture techniques, immunohistochemistry, apoptosis, DNA repair foci assays, SNP analysis, western blotprotein expression, etc. 

Research team

  • Prof. Dr. Anne Vral, associate Porfessor, principal investigator
  • Prof. Dr. Ans Baeyens, associate professor, principal investigator
  • Jeroen Vierstraete, doctoral fellow
  • Mattias Van Heetvelde, doctoral fellow
  • Flavia Zita Francis, doctoral fellow
  • Leen Pieters, technician
  • Greet De Smet, technician
  • Johanna Aernoudt, technician
  • Toke Thiron, technician
  • Stephanie Vermeulen, technician

Key publications

  • Radiation Sensitivity of Human CD34(+) Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects, Radiat Res. 2016 Jun;185(6):580-90. doi: 10.1667/RR14109.1. Epub 2016 May 19. (PMID: 27195608)
  • Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation, Breast Cancer Res. 2016 May 17;18(1):52. doi: 10.1186/s13058-016-0709-1. (PMID: 27184744)
  • BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer, BMC Cancer. 2015 Nov 17;15:912. doi: 10.1186/s12885-015-1913-6. (PMID: 26577449)
  • Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa, Mol Med Rep. 2016 Jan;13(1):130-6. doi: 10.3892/mmr.2015.4504. Epub 2015 Nov 5. (PMID: 26549042)
  • Early biomarkers related to secondary primary cancer risk in radiotherapy treated prostate cancer patients: IMRT versus IMAT, Radiother Oncol. 2013 Jun;107(3):377-81. doi: 10.1016/j.radonc.2013.05.014. Epub 2013 Jun 19. (PMID: 23791364)
  • Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives, Neuromolecular Med. 2013 Sep;15(3):447-57. doi: 10.1007/s12017-013-8231-4. Epub 2013 Apr 30. (PMID: 23632773)
  • Topographic and quantitative relationship between prostate inflammation, proliferative inflammatory atrophy and low-grade prostate intraepithelial neoplasia: a biopsy study in chronic prostatitis patients, Int J Oncol. 2012 Dec;41(6):1950-8. doi: 10.3892/ijo.2012.1646. Epub 2012 Oct 1. (PMID: 23026863)
  • Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity, Mol Med Rep. 2011 Sep-Oct;4(5):901-12. doi: 10.3892/mmr.2011.523. Epub 2011 Jul 1. (PMID: 21725594)

Contact & links

  • Department of Basic Medical Sciences, Radiobiology Research Group, Campus Heymans, University Hospital, building 6B3, Corneel Heymanslaan 10, 9000 Gent, Belgium
  • Autobeeldanalyse
  • Biodosimetrie