Neuroblastoma is a pediatric tumor responsible for 10-15% of childhood cancer deaths. Half of the neuroblastoma patients belong to the high-risk group of which half will relapse and die of their disease, despite intensive therapies.
Technological advancements in single-cell research have highlighted the intra-tumor heterogeneity in various cancer entities, including neuroblastoma. My research focuses on single-cell RNA-sequencing (scRNA-seq) to identify malignant subclones and cell-states in order to generate new insights into the molecular mechanisms of metastasis and therapy resistance. In this way, I hope to facilitate the development of more effective precision oncology strategies for high-risk neuroblastoma.