Neuroblastoma is a pediatric tumor responsible for 10-15% of childhood cancer deaths. Half of the neuroblastoma patients belong to the high-risk group of which half will relapse and die of their disease, despite intensive therapies.
Technological advancements in single-cell research have highlighted the intra-tumor heterogeneity in various cancer entities, including neuroblastoma. My research focuses on single-cell RNA-sequencing (scRNA-seq) to identify malignant subclones and cell-states in order to generate new insights into the molecular mechanisms of metastasis and therapy resistance. In this way, I hope to facilitate the development of more effective precision oncology strategies for high-risk neuroblastoma.
Contact & links
- Lab address: VIB Center for Medical Biotechnology
UGent Department of Biomolecular Medicine
Technologiepark-Zwijnaarde 75 - 9052 Gent – BELGIUM
- VIB-UGent Center for Medical Biotechnology (CMB)
- TOBI lab
- Center for Medical Genetics Ghent
- Noah Bonine is interested to receive invitations for presentations or talks