Prof. Charlotte Scott (PhD)
Professor of Immunology at Ghent University (Faculty of Science / Department of Biomedical Molecular Biology)
Principal Investigator at VIB-IRC (Lab of Myeloid Cell Biology in Tissue Damage and Inflammation)
Research focus
Our research is focused on understanding (i) the different types of macrophages (immune cells) present in and around tumour tissues and (ii) what these different cells do in terms of promoting or preventing tumour growth and spread. We use a range of techniques to address this question, focusing recently on multi-omics methods including single cell/nuclei RNA-sequencing and spatial proteogenomics approaches. These methods allow us to probe what cells are present and where exactly they are in the tissue. This can of course also shed light on which other cells the macrophage populations of interest are interacting with, which further allows us to investigate their functions as well as signals that may regulate their presence in these regions. Using an array of mouse models, we examine the consequences of lacking specific genes in these different macrophages or lacking the different macrophage populations themselves. By understanding this, we aim to be able to move one step closer to utilizing these cells for cell therapy based approaches, aiming to prevent and/or reverse tumour growth.
Research team
- Professor Charlotte Scott (PhD) - principal Investigator, full professor
- Liesbet Martens - senior bio-IT informatician
- Tinne Thone - bio-IT informatician
- Bavo Vanneste - expert lab technician
- Fleur Parmentier - senior lab technician
- Ismael Varela Tang - senior lab technician
- dr. Annelies Van Hemelryk (MD, PhD) - post-doctoral researcher
- dr. Paul Collins (PhD) - post-doctoral researcher
- Sara Maggiore - doctoral fellow
- Noah Bonine - doctoral fellow
- Lasse Vleminckx - doctoral fellow
Key publications
- NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors, Cell Reports, In press.
Contact & links
- Lab address: VIB-UGent, Center for Inflammation Research, Technologiepark-Zwijnaarde 71, 9052 Ghent, Belgium
- Scott Lab
- X(former Twitter)
- Google Scholar
- Prof. Charlotte Scott is interested to receive invitations for presentations or talks