Doctoral fellow - Lab of computational cancer genomics and tumour evolution (Faculty of Medicine and Health Sciences, UGent)
Principal investigator: prof. Jimmy Van den Eynden (MD, PhD)
My research explores computational approaches to study how the immune system shapes the mutational landscape of tumours.
Carcinogenesis can be regarded as an evolutionary process at the cellular level where cells gradually acquire subsequent somatic mutations that result in a fitness advantage and clonal expansion. A developing tumour is under permanent surveillance by the immune system and needs to develop adaptive mechanisms to evade immune-mediated cancer cell elimination, a process referred to as immunoediting.
The goal of my research is to gain deeper insights in this immunoediting process by studying somatic mutation patterns in large cancer genome sequencing data, ultimately aiming at improving cancer (immuno)therapy responses.
I obtained a Bachelor of Science in Computer Science in 2016 and a Master of Science in Bioinformatics (Engineering track) in 2018, both at Ghent University. In 2019, after completing the first year of the master’s programme in biomedical engineering, I joined the lab of Jimmy Van den Eynden as a PhD student.
- Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals. PLoS Genetics, 2021. (PMID: 33556087)
- ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation. EMBO Journal, 2021 (PMID: 33411331)