Sudip Ghosh
Doctoral Fellow – Organic and Biomimetic Chemistry Research Group – Faculty of Sciences - UGent
Principal investigator: prof. Annemieke Madder (PhD)
Research focus
My PhD project is part of the interuniversity iBOF research project SOCan, which aims to develop a ground-breaking photoelectrochemistry-based ‘SOCan technology’ for the fast detection of clinically relevant levels of nucleic acid cancer biomarkers in patient samples. SOCan will address these bottlenecks in current molecular testing methods by developing, optimizing and validating an innovative solution to detect DNA alterations and RNA, selectively and specifically. The technology relies on singlet oxygen-based photoelectrochemistry and combines
(i) photosensitizers that produce singlet oxygen upon illumination;
(ii) capture and detection probes;
(iii) redox reporters; and
(iv) magnetic beads for immobilization and enhancing sensitivity.
Such a platform is highly sensitive, robust, fast, easy to setup and allows for re-use. My specific task is concerned with the development of optimized capture probes that allow highly selective and sensitive detection of a specific target nucleic acid biomarker.
Biography
I earned my Master of Science in Chemistry from the Indian Institute of Science (IISc), Bangalore. Followingly, I worked as a research scholar in the Department of Organic Chemistry at IISc, where I gained expertise in peptide chemistry.
Currently, I am pursuing PhD in organic chemistry in the OBCR group under the supervision of Prof. Annemieke Madder. I am a part of the SOCan Project.
My research focuses on using furan cross-linking methods to covalently trap cancer nucleic acid biomarkers. Key areas include the synthesis of chemically modified oligonucleotides, photo-electrochemical detection.
Contact & links
- Lab address: Campus Sterre, Krijgslaan 281, Building S4, 9000 Gent, Belgium
- Madder lab
- Sudip Ghosh is interested to receive invitations for presentations or talks