Nidda Saeed

My research focuses on advancing locoregional drug delivery strategies for the treatment of peritoneal carcinomatosis, with emphasis on enhancing nanoparticle penetration into peritoneal tissues. Traditional approaches are limited by poor drug distribution; thus, my work explores novel techniques such as Electromotive Drug Administration (EMDA) and Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC).
In this project, we developed a custom in vitro and ex vivo model simulating EMDA conditions to investigate how externally applied electric fields can actively drive nanoparticle transport through peritoneal tissue. In parallel, ePIPAC is studied as a complementary technique that combines high-pressure aerosol delivery with an electrostatic field to improve nanoparticle dispersion and tissue uptake. We are evaluating various controlled-release nanoparticle systems and employing Fluorescence Lifetime Imaging Microscopy (FLIM) to quantitatively assess drug penetration and distribution in peritoneal tissues. Promising findings from these models are being translated into in vivo studies using a rat model of peritoneal carcinomatosis.
This innovative work was recently recognized with an Oral Presentation Prize at the 14th International NanoMedicine Conference in Sydney, Australia, highlighting its impact in the field of cancer nanomedicine.
 

• Electromotive Enhanced Drug Administration in Oncology: Principles, Evidence, Current and Emerging Applications, Cancers (2022)
• Assessment of Awareness and Knowledge of Breast Cancer in Pakistani Females; A Quantitative Study published in Pakistan, Journal of Life and Social Sciences. (May,2019), P-ISSN: 1727-4915.
• 99mTc-tazobactam a novel infection imaging agent: Radio synthesis, Quality control, Bio distribution and Infection imaging studies ,Journal of Labelled compounds and Radiopharmaceuticals. (Feb,2017)
• Evaluation of the Hemogram of Breast Cancer Patients Treated by Therapeutic Protocol Based on Immunohistochemical Analysis: A Retrospective Study published in Journal of Antivirals & Antiretrovirals. (January, 2017) DOI: 10.4172/1948-5964.1000154
   

• Lab address: Experimental Surgery Lab, campus UZ Gent, 
  C. Heymanslaan 10, The Core, ingang 37, verdieping 3
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• Nidda Saeed is interested to receive invitations for presentations or talks