Nidda Saeed

CRIG member

Doctoral fellow  - Experimental Surgery Lab (Faculty of Medicine and Health Sciences, UGent) & Lab of General Biochemistry and Physical Pharmacy (Faculty of Pharmaceutical Sciences, UGent) & Faculty of Engineering and Architecture, UGent
Principal investigators: prof. Wim Ceelen (MD, PhD) and prof. Katrien Remaut (PhD)


Research focus

During the standard treatment regimen of Peritoneal Cancer, patients receive intraperitoneal instillation of chemotherapeutics after initial cytoreductive surgery. The clinical use of new administration techniques such as pressurized intraperitoneal aerosol chemotherapy (PIPAC) is however promising. Moreover, innovative pharmaceutical platforms such as nanoparticles and controlled release systems are thought to further boost locoregional drug delivery. 
The Research project focuses on the aspects of a novel delivery technique (ePIPAC: electrostatic pressurized intraperitoneal aerosol chemotherapy) to deliver Nanoparticles to the peritoneal cavity, to treat peritoneal carcinomatosis. The main research questions involve exploring the mechanisms that govern NP penetration in healthy and tumor tissue after Intraperitoneal aerosol delivery under the influence of an external electrical and/or electrostatic field. Therefore, we developed an ex vivo model to test the effect of high pressure nebulization of nanoparticles on isolated peritoneal tissue. Different controlled release systems will be evaluated in vitro and further optimized in vivo in a rat model of peritoneal carcinomatosis using different techniques.

Key publications

Contact & links

  • Lab address: Experimental Surgery Lab, campus UZ Gent, 
    C. Heymanslaan 10, The Core, ingang 37, verdieping 3
  • LinkedIn
  • Nidda Saeed is interested to receive invitations for presentations or talks