Doctoral fellow - Experimental Surgery Lab (Faculty of Medicine and Health Sciences, UGent) & Lab of General Biochemistry and Physical Pharmacy (Faculty of Pharmaceutical Sciences, UGent) & Faculty of Engineering and Architecture, UGent
Principal investigators: prof. Wim Ceelen (MD, PhD) and prof. Katrien Remaut (PhD)
During the standard treatment regimen of Peritoneal Cancer, patients receive intraperitoneal instillation of chemotherapeutics after initial cytoreductive surgery. The clinical use of new administration techniques such as pressurized intraperitoneal aerosol chemotherapy (PIPAC) is however promising. Moreover, innovative pharmaceutical platforms such as nanoparticles and controlled release systems are thought to further boost locoregional drug delivery.
The Research project focuses on the aspects of a novel delivery technique (ePIPAC: electrostatic pressurized intraperitoneal aerosol chemotherapy) to deliver Nanoparticles to the peritoneal cavity, to treat peritoneal carcinomatosis. The main research questions involve exploring the mechanisms that govern NP penetration in healthy and tumor tissue after Intraperitoneal aerosol delivery under the influence of an external electrical and/or electrostatic field. Therefore, we developed an ex vivo model to test the effect of high pressure nebulization of nanoparticles on isolated peritoneal tissue. Different controlled release systems will be evaluated in vitro and further optimized in vivo in a rat model of peritoneal carcinomatosis using different techniques.
- Assessment of Awareness and Knowledge of Breast Cancer in Pakistani Females; A Quantitative Study published in Pakistan, Journal of Life and Social Sciences. (May,2019), P-ISSN: 1727-4915.
- 99mTc-tazobactam a novel infection imaging agent: Radio synthesis, Quality control, Bio distribution and Infection imaging studies ,Journal of Labelled compounds and Radiopharmaceuticals. (Feb,2017)
- Evaluation of the Hemogram of Breast Cancer Patients Treated by Therapeutic Protocol Based on Immunohistochemical Analysis: A Retrospective Study published in Journal of Antivirals & Antiretrovirals. (January, 2017) DOI: 10.4172/1948-5964.1000154