Doctoral Fellow- Leukemia Therapy Resistance Lab (LTR)- Center for Medical Genetics & Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences – Ghent University
Principal investigator: prof. Panos Ntziachristos (PhD)
Acute leukaemia is a very prevalent cancer in kids and adults and currently the main problem about this disease is that 25% of children and 50% of adults develop resistance to therapy or relapse post therapy. Moreover, mechanisms of resistance are poorly understood and current research on oncogenesis mainly focuses on gene mutations, that however seem to explain only 15-20% of high-risk disease cases. In recent years, the lab has been dissecting the molecular roles of different splicing factors and in my project, I will be focusing on characterizing and targeting aberrant splicing activity in acute lymphoblastic leukaemia, by studying novel relevant targets within the splicing machinery. These studies could enlarge the spectrum of potential drug targets available and help implement our understanding of resistance to therapy in the clinical setting.