Robin De Backer

The aim of my research is to contribute to the design of therapeutic strategies to target transcription factors involved in leukemia pathways with a focus on acute leukemia. Transcription factors have long been regarded as “undruggable”. However, advances in the field, in particular  approaching such a challenge  via a combination of medicinal and computational chemistry and structural biology  together with appropriate cellular studies, have  made the targeting of transcription factors a more tractable problem. Thus, we will work as part of an interdisciplinary consortium to develop lead compounds with anti-leukemic properties against therapeutically validated transcription factors in acute leukemia. My key focus is the structural biology approach where insights in the structure of involved proteins will be used to perform structure-based hit optimization.  
 

• Lab address: VIB-Ugent Center for Inflammation Research, Technologiepark 71, 9052 Zwijnaarde, Belgium 
• Savvides Lab 
• ORCID 
• LinkedIn 
• Robin De Backer is interested to receive invitations for talks and presentations