Lumicks webinar on Cell Avidity - a key parameter to understand and optimize immune cell therapy and cell engagers
Webinar - organized by Lumicks for CRIG and UGent - on Cell Avidity: a key parameter to understand and optimize immune cell therapy and cell engagers
- Speaker: Dr. Yash Patankar (Technical Sales Specialist from LUMICKS)
- Date and time: Friday 1 July at 13:00
- register via this link
Description:
Recent studies have revealed that the overall binding strength (or cell avidity) between T cells and tumour cells represents a crucial parameter for identifying and developing potent cancer immunotherapies. Unlike affinity, cell avidity is driven by a multitude of factors, including receptor density, affinity, the engagement of co-receptors and T-cell engagers. Whether exploring T cells such as TCR or CAR-T, NK cell function, or cell engagers, cell avidity is providing new insights into downstream events and therapeutic effectiveness. One of the main obstacles in measuring avidity is the lack of fast, specific, and accurate technologies. The z-Movi® Cell Avidity Analyzer is a novel and unique instrument for direct measurement of cell–cell interaction strength using acoustic forces. This new technology provides predictive, reproducible and fast high-throughput results at a single-cell level. In this talk, we will highlight our recent cell avidity case studies with an emphasis on TCR, CAR-T and cell engagers.