Yuri Bastos Moreira
Pregnancy remains a challenging period in the life of many women in low- and middle-income countries. Maternal mortality remains prevalent, and many newborns suffer from premature delivery and /or gestational growth retardation. The exposome is defined as the totality of human environmental (i.e., non-genetic factors) exposures, starting from conception, and how those exposures affect life and well-being. The exposome and nutrition have a significant effect on maternal and newborn health. Blood, urine and stool samples of mothers-newborns pairs (n=300), from a rural setting in Burkina Faso, were collected and assessed for the impact of environmental exposure to toxic compounds, such as mycotoxins and black carbon, and the supplementation effect on aging markers like the telomere length.
These hypotheses will be investigated through a poly-omic approach e.g., metabolomics, metagenomics, proteomics and adductomics. This is the first exposomics study in rural Burkina Faso, capillary blood samples collected in 20 µL Mitra tips will be used for the assessment of human exposure to multiple mycotoxins. Mycotoxins are significant to cancer research because long-term exposure can cause toxic effects such as genetic changes in target organs, resulting in cancer. Additionally new microsampling tools, plasma and stool samples will be analysed by multi-omics approaches along with advanced analytical tools. Omics data will play a significant part in the discovery of useful biomarkers for cancer research.
Contact & links
- Lab address: Ottergemsesteenweg 460 – 9000 Ghent
- Centre of Excellence in Mycotoxicology and Public Health
- Member MYTOX-SOUTH (UGent): an intercontinental partnership striving to solve mycotoxin problems
- Yuri Bastos Moreira is interested to receive invitations for presentations or talks