PhD fellow – Centre of Excellence in Mycotoxicology and Public Health (Faculty of Pharmaceutical Science, UGent)
Member MYTOX-SOUTH (UGent)
Principal investigator: prof. Sarah De Saeger (PhD)
Oesophageal cancer (EC) is a leading cause of mortality and morbidity among all cancers worldwide. EC has a poor prognosis, with a more severe outcome observed in low-income settings. Oesophageal squamous cell carcinoma (ESCC) is the most common EC histology. The highest ESCC incidence rates have been observed in Eastern to Central Asia (Asian Belt) and the easterly stretch of Africa (African Belt). While the aetiology of ESCC is well-documented in the ‘Asian belt’, data for the ‘African belt’ and the entirety of sub-Saharan Africa (SSA) is inadequate.
Intending to unravel exposures associated with ESCC aetiology, we aim to profile DNA adducts in case-control studies in SSA. DNA adduct formation is thought to be a necessary step in carcinogen-induced tumorigenesis – making DNA adductomics a classical -omics approach for studying ESCC aetiology. Understanding molecular mechanisms of ESCC tumorigenesis will be imperative for designing primary prevention and control strategies in high incidence regions of SSA.
Trancizeo seeks to understand toxicological effects of chronic environmental and lifestyle exposures in Oesophageal Cancer (EC) tumorigenesis. Using human biospecimens and cell lines, he intends to define EC aetiology by profiling DNA adducts in high EC incidence regions of sub-Saharan Africa.
Main interests in Cancer Research
- DNA adductomics
- Mechanistic toxicology
- Biomarker identification
- Risk assessment and health policy
Awards & Recognition
- Ph.D. fellow in Pharmaceutical Sciences, Ghent University (Special Research Fund, BOF 01W03419), Belgium
- M.Sc. Infection Biology, University of Glasgow (Beit-Glasgow Biomedical Fellowship), United Kingdom
- B.Sc. Biomedical Sciences, Mzuzu University (Public University Scholarship), Malawi
Contact & links
- Lab address: Department of Bioanalysis, Centre of Excellence in Mycotoxicology & Public Health, Campus Heymans, Faculty of Pharmaceutical Sciences, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
- COE in Mycotoxicology and Public Health
- Google Scholar
- Trancizeo Lipenga is interested to receive invitations for presentations or talks