prof. Serge Van Calenbergh (PhD)

CRIG member
Serge Van Calenbergh

Principal investigator - Lab for Medicinal Chemistry (Faculty of Pharmaceutical Sciences, UGent)
Full professor (Faculty of Pharmaceutical Sciences, UGent)
Director of studies (Faculty of Pharmaceutical Sciences, UGent)


Research focus

A large part of our work concentrates on the design and synthesis of small molecule modulators of new (i.e., yet unexplored) targets. These modulators can be both enabling chemical tools to interrogate biology or therapeutically useful compounds. From a chemical point of view, much of our work is centered on the chemical synthesis of original nucleoside analogues, some of which demonstrate promising antiparasitic and antitumor activities, and PROTACs for targeted protein degradation. We have constructed a PROTAC reagent toolbox, which allows swift conjugation of different E3 ligase binders to ligands for the target protein of choice. 

Research team

Contact & links