prof. Serge Van Calenbergh (PhD)
Principal investigator - Lab for Medicinal Chemistry (Faculty of Pharmaceutical Sciences, UGent)
Full professor (Faculty of Pharmaceutical Sciences, UGent)
Director of studies (Faculty of Pharmaceutical Sciences, UGent)
Research focus
A large part of our work concentrates on the design and synthesis of small molecule modulators of new (i.e., yet unexplored) targets. These modulators can be both enabling chemical tools to interrogate biology or therapeutically useful compounds. From a chemical point of view, much of our work is centered on the chemical synthesis of original nucleoside analogues, some of which demonstrate promising antiparasitic and antitumor activities, and PROTACs for targeted protein degradation. More recently we started to explore the structure-activity relationship of Pelophen B-analogues, which stabilize microtubules through interaction with a non-taxoid binding site of β-tubulin.
Research team
- dr. Martijn Risseeuw (PhD) - post-doctoral fellow
- Chaimae El Hadri - doctoral fellow
- Anouk Van Hauwermeiren - doctoral fellow
- Hanne Van de Putte - doctoral fellow
Contact & links
- Faculty of Pharmaceutical Sciences, LabMedChem, Ottergemsesteenweg 460 (Blok B), B-9000 Gent
- Laboratory for Medicinal Chemistry