prof. Richard Hoogenboom (PhD)
Head of the Supramolecular Chemistry Group
Full professor (Department of Organic and Macromolecular Chemistry, Faculty of Sciences, UGent)
Member of the Center of Macromolecular Chemistry (CMaC)
The main focus of the lab is on polymer chemistry and we develop polymer-conjugates for therapeutics, diagnostics and drug delivery. we master the technology of making highly defined polymer chains with up to three specific functional groups that can be used for attachment of eg drugs (via cleavable linkers) of next generation PEGylation, targeting groups (including antibodies or nanobodies) and labels (radionuclides or fluorescent). Moreover, we develop block copolymers as basis for nanocarriers for drugs and biologicals. Recent activities are focused towards the development of non-viral polymeric vectors for gene therapy, including mRNA, saRNA, pDNA and siRNA transfection.
Richard Hoogenboom (1978) studied chemical engineering at the Eindhoven University of Technology (the Netherlands). In 2005, he obtained his Ph.D. under the supervision of Ulrich S. Schubert and continued working as a project leader for the Dutch Polymer Institute. After postdoctoral training with Martin Moeller and Roeland Nolte, he was appointed as associate professor at Ghent University in 2010 and in October 2014 he was promoted to full professor. His research interests include stimuli-responsive polymers, supramolecular polymers, and poly(2-oxazoline)s. He has published > 400 scientific articles and is currently editor-in-chief for European Polymer Journal and associate editor for Australian Journal of Chemistry. Prof. Hoogenboom is the recipient of the inaugural Polymer Chemistry Lectureship (2015), the fifth PI IUPAC award (2016) and the ACS Macromolecules/Biomacromolecules young investigator award (2017).
- Linear Poly(ethylenimine-propylenimine) Random Copolymers for Gene Delivery: From Polymer Synthesis to Efficient Transfection with High Serum Tolerance, MR Elzes, I Mertens, O Sedlacek, B Verbraeken, ACA Doensen, MA Mees, M Glassner, S Jana, JMJ Paulusse, R Hoogenboom Biomacromolecules 2022, 23, 2459-2470
- ChemicalDesign of Non‐Ionic Polymer Brushes as Biointerfaces: Poly (2‐oxazine) s Outperform Both Poly (2‐oxazoline) s and PEG. G Morgese, B Verbraeken, SN Ramakrishna, Y Gombert, E Cavalli, R.Hoogenboom, ... Angewandte Chemie International Edition 57 (36), 11667-11672
- UnexpectedReactivity Switch in the Statistical Copolymerization of 2 Oxazolines and2-Oxazines Enabling the One-Step Synthesis of Amphiphilic Gradient Copolymers. O Sedlacek, K Lava, B Verbraeken, S Kasmi, BG De Geest and R. Hoogenboom. Journal of the American Chemical Society
- Poly(2-ethyl-2-oxazoline) conjugates with doxorubicin for cancer therapy: In vitro and in vivo evaluation and direct comparison to poly [N-(2-hydroxypropyl)methacrylamide analogues. O Sedlacek, BD Monnery, J Mattova, J Kucka, JPanek, O Janouskova, R. Hoogenboom, ... Biomaterials 146, 1-12