'Ferroptosis at the crossroads of cancer- acquired drug resistance and immune evasion' : article in Nature Reviews Cancer with CRIG affiliation

CRIG

CRIG group leader prof. Dmitri Krysko is co-author on an opinion article about ferroptosis in Nature Reviews Cancer. Ferroptosis is a recently recognized distinct cell death type that has emerged to play an important role in cancer biology. As such, metabolic reprogramming of plastic cancer cells has been linked to an acquired sensitivity to ferroptosis, opening up new opportunities to treat therapy-insensitive tumours. A better understanding of the processes that regulate this ferroptosis sensitivity is instrumental in the discovery of novel therapeutic strategies. Therefore, in this article you can find an overview of the known mechanisms that regulate sensitivity to ferroptosis in cancer cells and how the modulation of metabolic pathways controlling ferroptosis might reshape the tumour niche, leading to an immunosuppressive microenvironment that promotes tumour growth and progression.

Read the full article here !