Metabolomics platform

The Laboratory of Integrative Metabolomics (LIMET), led by Prof. Lynn Vanhaecke, has established expertise in developing and applying advanced mass spectrometry-based omics methods for small molecules, including (semi)quantitative, targeted, and untargeted approaches, to address research questions related to food safety, public health, and individual well-being.

The metabolome provides a comprehensive and accurate assessment of biological states by integrating signals from endogenously produced metabolites, driven by (epi)genetic regulation, with inputs from the exposome (e.g., environment, diet, and microbiome). As metabolic changes are highly dynamic and sensitive, they reflect (patho)physiological conditions at an early stage, often before structural changes in e.g. cancerous cells become apparent. This makes metabolomics a powerful tool for cancer research, particularly in biomarker discovery and early-stage detection. LIMET employs cutting-edge UHPLC-HRMS technology (Thermo Fisher Q-Exactive and Exploris 120, coupled to single and dual pump UHPLC units, respectively) to map metabolomic fingerprints across diverse biological matrices, including feces, digestive fluids, urine, blood serum and plasma, tissues, cell lines, and saliva. 
CRIG members and other interested researchers are welcome to inquire about sample requirements, collaborative opportunities, and analysis costs.

 

Department of Translational Physiology, Infectiology and Public Health, Laboratory of Integrative Metabolomics, Salisburylaan 133, 9820 Merelbeke
 

prof. Lynn Vanhaecke