Laure De Pryck
Doctoral fellow - Lab of Nico Callewaert, Center for Medical Biotechnology – VIB-Ugent (Faculty of Science)
Principal investigator: prof. Nico Callewaert (PhD)
CAR-T cell therapy has recently revolutionized the field of cancer immunotherapy. In this application, a patient’s own immune cells are engineered to allow them to recognize cancer cells when brought back into the patient. Despite some great successes in the treatment of blood cancers, the therapy is still faced with a lot of obstacles in order to become effective for the treatment of solid tumors. One major limiting factor is the immunosuppressive tumor microenvironment.
In our project, we will use genome engineering techniques, such as CRISPR-Cas9, to alter immunosuppressive pathways in the CAR-T cells.