Jordy De Coninck
Labtechnician/bioinformatician – Molecular and Cellular Oncology Lab - UGent - WE14
Principal investigator: prof. Geert Berx (PhD)
Our research interests are aimed at combating cancer by unraveling the molecular mechanisms underlying malignant tumor progression. This is motivated by the fact that 90% of cancer patients die of metastasis and that metastatic dissemination of tumor cells is not only induced by genotypic or phenotypic changes within the tumor cells themselves but also by the microenvironment. More recently we became strongly interested in mechanisms of cellular plasticity.
As such we developed interest in EMT, which currently focuses on the in vivo function of EMT-related transcription factors during inflammation driven cancer.
We use in vivo EMT models for melanoma, skin, ovarian and breast cancer, immunity and inflammation research and functional genomic techniques, single cell analysis, reversed genetic screenings to uncover gene-expression profiles, epigenetic changes and various signaling pathways that modulate EMT in immune and cancer cells.