Hooman Salavati

CRIG member
Hooman Salavati


Doctoral fellow  - Experimental Surgery Lab, Faculty of Medicine and Health Sciences, UGent.
Doctoral fellow  - IBiTech-Biommeda, Faculty of engineering and architecture, UGent
Principal investigators: prof. Wim Ceelen (MD, PhD) and prof. Charlotte Debbaut (PhD)

 

Research focus

It has been clearly understood that the tumor stromal biophysical properties heavily affect the income of any cancer therapy, such as chemotherapy.
In my doctoral researches, I will focus on developing non-invasive methods for profiling crucial biophysical parameters in solid tumors including the interstitial fluid pressure and elastic features. For doing so, a clinical study has been planned to implement the dynamic contrast-enhanced MRI (DCE-MRI) for developing a personalized cancer characterization during therapy. Also, few other in-vitro investigations such as hydraulic conductivity measurement is undergoing, which finally a 3D coupling of poroelastic and computational fluid dynamics models will illustrate the outcomes.
 

Biography

CRIG AWARDS:

  • Storm pitch award, Oncodot 3 by CRIG (online symposium, Gent, Belgium), 28 April 2021
  • Best poster award, 8th OncoPoint symposium by CRIG (Gent, Belgium), 23 May 2022
     

Key publications

  • The pivotal role of angiogenesis in a multi-scale modeling of tumor growth exhibiting the avascular and vascular phases, Microvascular Research, 2018 (PMID: 29742454)
  • The impact of endothelial cells proliferation in a multiscale realistic reproduction of angiogenesis, Biochemical Engineering Journal, 2019 (DOI: 10.1016/j.bej.2018.11.012)
  • Interstitial fluid pressure as an emerging biomarker in solid tumors. Biochimica et Biophysica Acta (BBA)- Reviews on Cancer, 2022 (PMID: 36084861; DOI: 10.1016/j.bbcan.2022.188792)
  • Biomechanical aspects of the normal and cancer-associated lymphatic system. The Lymphatic System in Colorectal Cancer, 2022 (DOI: 10.1016/B978-0-12-824297-1.00006-3)
     

Contact & links

  • Lab address: Campus Ghent University Hospital (UZ Gent), entrance 36, Corneel Heymanslaan 10, Ghent 9000, Belgium
  • LinkedIn
  • Biommeda website
  • Hooman Salavati is interested to receive invitations for presentations or talks