It has been clearly understood that the tumor stromal biophysical properties heavily affect the income of any cancer therapy, such as chemotherapy.
In my doctoral researches, I will focus on developing non-invasive methods for profiling crucial biophysical parameters in solid tumors including the interstitial fluid pressure and elastic features. For doing so, a clinical study has been planned to implement the dynamic contrast-enhanced MRI (DCE-MRI) for developing a personalized cancer characterization during therapy. Also, few other in-vitro investigations such as hydraulic conductivity measurement is undergoing, which finally a 3D coupling of poroelastic and computational fluid dynamics models will illustrate the outcomes.
- The pivotal role of angiogenesis in a multi-scale modeling of tumor growth exhibiting the avascular and vascular phases, Microvascular Research, 2018 (PMID: 29742454)
- The impact of endothelial cells proliferation in a multiscale realistic reproduction of angiogenesis, Biochemical Engineering Journal, 2019 (DOI: 10.1016/j.bej.2018.11.012)
- Interstitial fluid pressure as an emerging biomarker in solid tumors. Biochimica et Biophysica Acta (BBA)- Reviews on Cancer, 2022 (PMID: 36084861; DOI: 10.1016/j.bbcan.2022.188792)
- Biomechanical aspects of the normal and cancer-associated lymphatic system. The Lymphatic System in Colorectal Cancer, 2022 (DOI: 10.1016/B978-0-12-824297-1.00006-3)