dr. Penthip Muangkaew (PhD)

My research is focused on the synthesis and development of cyclic lipodepsipeptide (CLiPs). These natural products, produced by Pseudomonas bacteria, are composed of a cyclic oligopeptide closed by an ester or ‘depsi’-bond and feature a fatty acid. Their biological properties are very diverse, making them the bacterial equivalent of a “Swiss Army Knife”. So far, interest has mainly focused on antimicrobial activity and antifungal activity. More recently, our attention has shifted to their promising anticancer potential. We are currently focusing on the fluorescent tagged CLiPs which would allow visualizing the peptide-cancer cell interaction using confocal microscopy.
 

• 2013: B.Sc., Chemistry, Faculty of Science, Naresuan University, Thailand
  Thesis title: Synthesis of diphenylmethyl ester of hydroxyproline with potassium permanganate
  (Supervisor: Asst. Prof. Dr. Chaturong Supharpprom)
• 2018 (May-Aug): Research trainee at Nagoya University, Nagoya, Japan
  Project title: Invasion study of linear probe combination with acpcPNA and acbcPNA targeting DNA duplex
  (Supervisor: Prof. Dr. Hiroyuki Asanuma)
• 2020 (Jan-April): Research trainee at University of Ghent, Ghent, Belgium 
  Project title: Cross-linking study of furan modified aegPNA and acpcPNA towards complementary DNA target 
  (Supervisor: Prof. Dr. Annemieke Madder)
• 2021: Ph.D., Chemistry, Faculty of Science, Chulalongkorn University, Thailand
  Thesis title: Pyrrolidinyl peptide nucleic acid probe capable of crosslinking with DNA
  (Supervisor: Prof. Dr. Tirayut Vilaivan)
• 2021 – Present: Postdoctoral researcher at University of Ghent, Ghent, Belgium 
  Scope: the synthesis of Fluorescent Cyclic Lipodepsipeptides to gain insight into their mode of action
  (Supervisor: Prof. Dr. Annemieke Madder)
   

• ‘Pyrrolidinyl Peptide Nucleic Acid Probes Capable of Crosslinking with DNA: Effects of Terminal and Internal Modifications on Crosslink Efficiency’. Chembiochem. 2021. (PMID: 32889765)
• ‘Modulation of DNA and RNA by PNA’. Bioorg Med Chem Lett. 2020. (PMID: 32147357)
• ‘Synthesis of Pyrrolidinyl PNA and Its Site-Specific Labeling at Internal Positions by Click Chemistry’. Methods Mol Biol., 2020. (PMID: 32088863)
• ‘Synthesis and structure-activity relationship of Peptide Nucleic Acid Probes with improved Interstrand-Crosslinking abilities: Application to Biotin-mediated RNA-Pulldown’. Microbiol Spectr. 2022. (PMID: 36128507) 
• ‘An Nuclear Magnetic Resonance Fingerprint Matching Approach for the Identification and Structural Re-Evaluation of Pseudomonas Lipopeptides’. RSC Chem. Biol, 2022. (PMID: 35876524) 
   

• Lab address: Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Krijgslaan 281, S4; 9000 Gent
• Madder lab 
• ORCID
• ResearchGate
• Linkedin
• Penthip Muangkaew is interested to receive invitations for presentations or talks