DNA adductomics platform
Accessible for academic and industrial partners
Decription
The Laboratory of Integrative Metabolomics (LIMET), led by Prof. Lynn Vanhaecke, has established expertise in developing and applying advanced mass spectrometry-based omics methods for small molecules, including (semi)quantitative, targeted, and untargeted approaches, to address research questions related to food safety, public health, and individual well-being.
DNA adducts originate from the interaction and subsequent covalent bonding between an electrophilic molecule and nucleophilic sites in DNA. The majority of DNA reactive molecules have the potential to lead to mutations and chromosomal alterations during DNA replication via formation of DNA adducts or DNA strand breaks. Therefore, DNA adduct formation is deemed to be the first step in chemically induced carcinogenesis. DNA adductome mapping offers a direct reflection of overall genotoxin exposure, metabolism and effect, and LIMET has established a validated UHPLC-HRMS DNA adductomics platforms (Thermo Fisher Q-Exactive and Exploris 120). This platform allows us to map the DNA adductome in different biological matrices.
CRIG members and other interested researchers are welcome to inquire about sample requirements, collaborative opportunities, and analysis costs.
Location
Department of Veterinary Public Health and Food Safety, Laboratory of Integrative Metabolomics (LIMET), Salisburylaan 133, B-9820 Merelbeke