Doctoral fellow - Laboratory of Biochemistry, Department of Veterinary and Biosciences (Faculty of Veterinary Medicine, UGent)
Principal investigator: prof. Evelyne Meyer (PhD)
Triple-negative breast cancer (TNBC), remain one of the deadliest cancers in women worldwide. Despite their positive effects in preclinical animal models, most of the new therapeutics fail in clinical trials, which has resulted in a high demand for preclinical models that are more representative for the human situation. As an answer to this urgent need, our group has developed an immunocompetent intraductal mouse model for TNBC that relies on the injection of triple-negative mouse mammary tumor cells through the teat canal into the mammary ducts of syngeneic and lactating female mice.
During my research we try to extend even further this existing mice model for TNBC by using a variety of TNBC cell lines. In order to further mimic the heterogeneity of the diseases found in human patients. This will be done by comparing and evaluating the tumor micro environment (TME) of these different TNBC tumors, such as immune cell composition within the TME. To further investigate immunological responses during both tumor growth and when exposed to immune therapy.