Doctoral fellow – Molecular and Cellular Oncology lab (UGent) – Inflammation Research Center (IRC) – Department of Biomedical Molecular Biology
Principal investigator: prof. Geert Berx (PhD)
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Compared to other types of cancer, it tends to grow and spread faster. Because of it’s lack of hormonal receptors, there are less treatment options for TNBC. Epithelial-mesenchymal transition (EMT) is considered to be a crucial process in the metastasis of this type of tumour. EMT is a dynamic and reversible process by which epithelial cells lose cell-cell contacts and acquire mesenchymal features.
Using patient samples, mice models, organoid models, single cell transcriptomics and functional biology, we aim to gain understanding of the molecular mechanisms that drive EMT and metastasis of TNBC. More specifically, how EMT alters the epigenetic landscape of TNBC cells and influences immune infiltration of the tumor.