prof. Serge Van Calenbergh (PhD)

A large part of our work concentrates on the design and synthesis of small molecule modulators of new (i.e., yet unexplored) targets. These modulators can be both enabling chemical tools to interrogate biology or therapeutically useful compounds. From a chemical point of view, much of our work is centered on the chemical synthesis of original nucleoside analogues, some of which demonstrate promising antiparasitic and antitumor activities, and PROTACs for targeted protein degradation. We have constructed a PROTAC reagent toolbox, which allows swift conjugation of different E3 ligase binders to ligands for the target protein of choice. 
 

• dr. Martijn Risseeuw (PhD) - post-doctoral fellow
• Simon Krols - doctoral fellow
• Chaimae El Hadri - doctoral fellow
   

• Faculty of Pharmaceutical Sciences, Ottergemsesteenweg 460, B-9000 Gent
• Laboratory for Medicinal Chemistry