prof. Lies Lahousse (PhD)

CRIG member
Lies Lahousse


Professor (Faculty of Pharmaceutical Sciences,  Ghent University)
Principal investigator Precision medicine for chronic complex diseases
Member Belgian Young Academy
Member Primary Care consortium on personalizing care for moderate complex patients.
Co-chair WG4 European Respiratory Society Clinical Research Collaborations (ERS-CRC) Chronic Airway DiSeases Early sTratification (CADSET) - personalizing treatment options for (early) asthma/COPD
Member International COPD Genetics Consortium (ICGC) on (epi)genetic determinants of COPD and COPD exacerbations
Member Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) on (epi)genetic determinants of lung function

 

Research focus

My research line in pharmacoepidemiology combines aspects of clinical pharmacology and clinical epidemiology and studies drug use and (side)effects in large numbers of people to support rational drug use thereby improving health outcomes in the population. My research group focuses on therapy adherence and precision medicine including optimizing the benefit risk ratio of approved drugs by studying heterogeneity among phenotypes, endotypes and underlying genetics with the ultimate goal of improving care of patients with chronic complex diseases e.g. asthma and COPD.  

By deep phenotyping and international collaboration in population genomics, we unravelled heritability and novel genetic variants of pulmonary function traits by genome-wide association studies. My group aims to further investigate these and other omics-data in interaction with approved drugs and translate pharmacogenomics into clinical practice.
 

Research team

  • Xander Bertels - doctoral fellow
  • dr. Barbara Putman (MD) - doctoral fellow
  • dr. Maxim Grymonprez (MD) - doctoral fellow
  • Ahmed Edris Mohamed - doctoral fellow
  • Anna Vanoverschelde - doctoral fellow
  • dr. Sara Wijnant (MD) - doctoral fellow
     

Key publications

  • The Obesity Paradox in Lung Cancer: Associations With Body Size Versus Body Shape. Ardesch FH, Ruiter R, Mulder M, Lahousse L, Stricker BHC, Kiefte-de Jong JC. Front Oncol. 2020 Nov 10;10:591110. doi: 10.3389/fonc.2020.591110. eCollection 2020.
  • Dietary mineral intake and lung cancer risk: the Rotterdam Study. Muka T, Kraja B, Ruiter R, Lahousse L, de Keyser CE, Hofman A, Franco OH, Brusselle G, Stricker BH, Kiefte-de Jong JC. Eur J Nutr. 2017 Jun;56(4):1637-1646. doi: 10.1007/s00394-016-1210-4. Epub 2016 Apr 12.)
     

Contact & links

  • Lab address: Faculteit Farmaceutische Wetenschappen, Campus Heymans, Ottergemsesteenweg 460, 9000 Gent
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