prof. Christophe Ampe (PhD)

CRIG group leader

professor - Faculty of Medicine and Health Sciences - Actin and Cell Migration Lab - UGent
member European Cytoskeletal Forum
member Ghent University MemCLip consortium

Research focus

Investigation of actin-based cell migration and cancer cell invasion via protein-focused approaches
Expertise in biochemistry, molecular biology and imaging-based in vitro (preclinical) analysis
Development of software tools for image processing and for standardized quantitative analysis of cell migration
Fundamental research on actin regulation in disease (e.g. HIV, testin-family)
Improvement of drug treatments (e.g. hepatocellular carcinoma, use of bacterial peptides)

Time for rethinking the different B-actin transgenic mouse models?(2020)
Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures(2020)
Community standards for open cell migration data(2020)
A new evolutionary model for the vertebrate actin family including two novel groups(2019)
Analysis of invasion dynamics of matrix-embedded cells in a multisample format(2018) - Series: Methods in Molecular Biology
Combination of EGFR inhibitor lapatinib and MET inhibitor foretinib inhibits migration of triple negative breast cancer cell lines(2018)
Surveillance of myelodysplastic syndrome via migration analyses of blood neutrophils : a potential prognostic tool(2018)
An emerging link between LIM domain proteins and nuclear receptors(2018)
Concerted biophysical and biological evaluation of Pseudomonas lipopeptides as a premise to unlock their application potential(2018) - Volume: 24
An end-to-end software solution for the analysis of high-throughput single-cell migration data(2017)