prof. Christian Stevens (PhD)

CRIG group leader
Christian Stevens

Head of the SynBioC Research group
Full professor, Department of Sustainable Organic Chemistry and Technology
Director "Green Chemistry Ghent"

 

Research Focus

Synthesis of anti-metastatic compounds

Synthesis of blebbistatin analogues

Biography

Prof. Dr. Ir. Christian V. Stevens (°1965) is professor at the Department of Sustainable Organic Chemistry and Technology at the Faculty of Bioscience Engineering (Ghent University). He graduated at the same department as bio-engineer in chemistry in 1988 and obtainded a PhD in 1992 as fellow of the National Fund for Scientific Research. During his PhD he also worked as a research assistant of the University of Southern California (USC), Los Angeles, USA with Prof. C.E. McKenna. After his PhD at Ghent University under the direction of Prof. N. De Kimpe, he did post-doctoral work at the Center for Heterocyclic Compounds at the University of Florida, USA under the direction of Prof. A. R. Katritzky as a NATO Research Fellow. He became group leader in the group of Prof. Katritzky in 1993. He returned as a postdoctoral fellow of the National Fund for Scientific Research. In 1994, he also made a short postdoctoral stay at the University of Alicante (Spain) under the direction of Prof. M. Yus. 
In 1995, he became group leader of the National Fund for Scientific Research and became guest professor in 1997 at Ghent University. In 2000, he became professor at the current Faculty of Bioscience Engineering and developed the research group SynBioC of which he is the director. He became full professor in 2014.

Research team

  • prof. Christian Stevens - principal investigator, full professor
  • dr. Bart Roman - post-doctoral fellow FWO
  • ir. Sigrid Verhasselt - Aspirant FWO

Key publications

  • 4-Fluoro-3’,4’,5’-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.  Eur. J. Med. Chem.  (2015).
  • Further studies on anti-invasive chemotypes: An excursion from chalcones to curcuminoids.  Bioorg. Med. Chem. Lett. (2015).
  • Chick heart invasion assay for testing the invasiveness of cancer cells and the activity of potentially anti-invasive compounds. JoVE, http://www.jove.com/video/52792, Journal of Visualized Experiments, issue 100, article number e52792, June 2015.
  • Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes.. Bioorg. Med. Chem. (2013).
  • Assessment of the Antineoplastic Potential of Chalcones in Animal Models. Curr. Med. Chem. (2013).
  • Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted anaologues. Bioorg. Med. Chem. (2012).

Contact & links

  • Coupure links 653, B- 9000 Gent
  • SyncBioC