Neuroblastoma is a pediatric cancer that is challenging to treat and often shows therapeutic resistance. Dynamic profiling of the tumor has the potential to improve treatment strategies. Current characterization methods are based on tissue biopsies, which are invasive and can hold significant risks of tumor rupture and damage to surrounding tissues. Alternatively, the tumor entity can be analyzed via liquid biopsies, where information is extracted from fragmented tumor DNA in the blood. Since liquid biopsies are obtained during a minimally invasive blood draw, it is possible to take repeated samples and apply this method in tumor follow-up during treatment and remission.
In the project I am working on, I aim to analyze tumor DNA from liquid biopsies to aid tumor profiling, study heterogeneity, and follow up on tumor recurrence.