Flow-cytometry-based cancer immunomics

This is an analytical pipeline allowing extensive immunophenotyping on cancer patient-derived biosamples, be it tissue or peripheral blood, using 11-color analytical flow-cytometry.

Immunophenotyping panels have been optimized to track and quantify the following populations: monocyte subsets, natural killer cell subsets, CD8 vs CD4 T-cells along with acitvation and exhaustion markers as well as proliferation index, B-cell subsets, dendritic cell subsets, myeloid-derived suppressor cell subsets, innate lymphoid cell subsets

Comprehensive immunophenotyping can provide valuable candidate biomarkers for response or resistance to specific cancer therapies, foremost but not exclusively immunotherapy. Recent evidence indicates that this type of theragnostic information can be extracted in a patient-friendly way from peripheral blood analysis instead of tumor tissue samples.
 

MRB2 2nd floor - UZ Gent campus
 

responsible PI and contact person: prof. Karim Vermaelen