Primary immunodeficiency diseases (PIDs) are a heterogenous group of rare genetic disorders of the immune system often diagnosed in young children. These disorders result from various underlying mutations, however a subgroup of PIDs is caused by defects in DNA double-strand break (DSB) repair. Affected patients are more prone to genomic instability, have high cancer risk and often display an enhanced sensitivity to ionizing radiation.
The goal of this PhD is to investigate the involvement of the homologous recombination (HR) repair pathway in the radiosensitivity of PID patients. A better understanding of the underlying mechanisms of radiosensitivity in these PID patients will allow modifications in screening modalities, more targeted therapies and may help in the development of novel therapies.
In 2018, I obtained a Master of Science (MSc) in Biomedical Sciences with a major in Tissue Engineering and Regenerative Medicine at Ghent University.
After graduation, I became a full-time PhD student at the lab of prof. Ans Baeyens.