dr. Gabrielle van Ramshorst (MD, PhD)

CRIG member
Gabrielle van Ramshorst


Post-doctoral fellow -  Department of gastrointestinal surgery
Member of Laboratory for Experimental Surgery
Principal investigator: prof. Wim Ceelen (MD,PhD)

Research focus

Patients with recurrent rectal cancer can be suitable for a curative approach by pelvic exenteration. This often requires multicompartmental pelvic resection with reconstructive techniques for creation of stomas, ileal conduits or flaps for neovaginas. Our aim is to offer patients the highest standard of surgical care whilst preserving quality of life.

Methods: Subprojects include:

  • to study prospectively collected quality of life data;
  • to study needs of female pelvic exenteration patients with regard to neovaginal reconstruction;
  • to study patterns of recurrence in clinical patients;
  • to study effects of minimally invasive surgery on surgical outcomes in a highly selected patient group;
  • to establish a small animal model

We are aiming to intensify international collaboration by performing multicenter research.
Anticipated results: We expect to improve patient selection for pelvic and vaginal reconstruction, compare outcomes for open and minimally invasive surgery, and to learn about recurrence patterns and adjuvant clinical techniques.

Conclusions: Improvement of clinical outcomes of recurrent rectal cancer is necessary and may be achieved by minimizing surgical trauma and improving patient selection. This aim will be accomplished by performing translational research, combining animal models with a prospective international multicenter cohort study of patients with (recurrent) rectal cancer.
 

Biography

Before surgical training, I performed three years of fulltime clinical research at Erasmus MC, Rotterdam, the Netherlans. I finished surgical training at Amsterdam UMC in 2016 and I am registered as a gastrointestinal surgeon and surgical oncologist in the Netherlands, Belgium, and the United Kingdom. My clinical fellowship was sponsored by the Dutch Cancer Society and consisted of dedicated training in colorectal surgery, including pelvic exenteration, gynaecological oncology and urological oncology at the Dutch Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam UMC and the Royal Prince Alfred Hospital in Sydney, Australië (Top 100 best hospitals Newsweek 2019). In 2019 I worked as a locum surgical oncologist at Glasgow Royal Infirmary Hospital in Scotland (also Top 100 best hospitals Newsweek 2019) before accepting my position as consultant surgical oncologist at Ghent University Hospital.

My main interests include pelvic exenteration surgery, locally advanced and recurrent rectal cancer, high sacrectomies, gynaecological oncology (ovarian, cervical and recurrent vaginal cancer), peritoneal carcinomatosis and retroperitoneal sarcomas. 

Scientific interests include pelvic exenteration, neovaginal reconstruction, peritoneal and lymphogenic metastases and complications. I am associate editor at Colorectal Disease and member of the editorial board of the International Journal of Gynaecological Oncology. Also, I regularly join (international) guideline commisions. 

Memberships

  • Surgical Society for Oncology (member International Committee)
  • European Society of Coloproctology (member Research Committee)
  • European Society for Gynaecological Oncology
  • European Society for Surgical Oncology
  • European Hernia Society
  • Association of Coloproctology of Great Britain and Ireland
  • Dutch Surgical Society
  • Dutch Society for Surgical Oncology
  • Dutch Society for Gastrointestinal surgery
  • Dutch Hernia Society
  • Working group Coloproctology
     

Research team

Key publications

  • Intraperitoneal chemotherapy for peritoneal metastases: an expert opinion. Expert Opin Drug Deliv. 2020 Mar 18:1-12. IF 3.829 Q1 
  • Complications and impact on quality of life of Vertical Rectus Abdominis Myocutaneous (VRAM) flaps for reconstruction in pelvic exenteration surgery. Accepted for publication by Diseases of the Colon & Rectum. IF 4.087 Q1
  • The PelvEx Collaborative. Pelvic exenteration for advanced nonrectal pelvic malignancy. Ann Surg 2019;270(5):899-905. IF 9.476 Q1
  • The Pelvex Collaborative. Palliative pelvic exenteration: a systematic review of patient-centered outcomes. Eur J Surg Oncol 2019 Jun 14. IF 3.379 Q1 
  • The Pelvex Collaborative. Minimally invasive surgery techniques in pelvic exenteration – A systematic and meta-analysis review. Surg Endoscopy 2018;32(12):4707-15. IF 3.209 Q1 
  • A qualitative study of development of a multidisciplinary case conference review methodology to reduce involved margins in pelvic exenteration surgery for recurrent rectal cancer. Colorectal Dis 2018;20(11):1004-13. IF 2.997 Q1
  • The PelvEx Collaborative. Factors affecting outcomes following pelvic exenteration for locally recurrent rectal cancer. Br J Surg 2018 May;105(6):650-7. IF 5.572 Q1 
  • The PelvEx Collaborative. Surgical and survival outcomes following pelvic exenteration for locally advanced rectal cancer: Results from an International collaboration. Ann Surgery 2019;269(2):315-21. IF 9.476 Q1 
  • Minimally invasive, laparoscopic and robotic assisted techniques versus open techniques for kidney transplant recipients: a systematic review. Eur Urol 2017;72(2):205-17. IF 17.581 Q1 
  • Small bites versus large bites for closure of abdominal midline incisions: results of a double blinded multicenter randomized trial (STITCH-trial). Lancet 2015 July 15. IF 44.002 Q1
     

Contact & links

  • Lab address: campus UZ Gent, Department of Gastrointestinal surgery; route 1275, Corneel Heymanslaan 10, 9000 Ghent, Belgium
  • Linkedin 
  • Twitter 
  • Google scholar 
  • dr. van Ramshorst is interested to receive invitations for presentations or talks