Diogo Estevao

CRIG member
Diogo Estevao

Doctoral fellow 
- Tumour and Microenvironment Interactions lab/ i3S-Institute for Research & Innovation in Health, University of Porto 
- Laboratory of Experimental Cancer Research (LECR), UGent
Principal investigators: prof. Maria José Oliveira (PhD) & prof. Olivier De Wever (PhD) 


Research focus

Studying the impact of ionizing radiation on bridging rectal cancer microenvironment and its iron metabolism, paving the way for the discovery of novel radioresistance mechanism.


Diogo did his bachelor’s in Biology during which he performed an internship at the Science Faculty of Masaryk University in Brno, under the Erasmus+ program. He also did an internship in the Center for Anatomy and Cell Biology in Vienna. After, he did his master project at the Portuguese Institute of Oncology in Porto (IPO-Porto), where his main goal was to explore the HPV-induced carcinogenesis by the expression of its oncoproteins in the K14-HPV16 transgenic mouse model. Currently, Diogo is performing his joint PhD bridging the Institute for Research & Innovation in Health (i3S) in Porto and the Cancer Research Institute Ghent (CRIG) in Ghent to investigate the radioresistance mechanisms in rectal cancer using 3D models and Omics approaches.

Key publications

  • Expression of LncRNAs in HPV-induced Carcinogenesis and Cancer Cachexia: A Study in K14-HPV16 Mice. Anticancer Research. 2022 (PMID: 35489755)
  • Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds for Studying Tumor-Stroma Interactions. Cancers (Basel). 2022. (PMID: 35053521)
  • Differential Incidence of Tongue Base Cancer in Male and Female HPV16-Transgenic Mice: Role of Female Sex Hormone Receptors. Pathogens 2021 (PMID: 34684173)
  • HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer. Journal of Pathology 2020. (PMID: 32488868)
  • Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice. Food & Function 2020. (PMID: 32222741)
  • HPV16 is sufficient to induce squamous cell carcinoma specifically in the tongue base in transgenic mice. Journal of Pathology 2020. (PMID: 31994197)
  • Hallmarks of HPV carcinogenesis: the role of E6, E7 and E5 oncoproteins in cellular malignancy” BBA Gene Regulatory Mechanisms 2019. (PMID: 30707946)
  • CRISPR-Cas9 Therapies in Experimental Mouse Models of Cancer. Future Oncology 2018 (PMID: 30027767)

Contact & links