Covaris sonicator S220

Platforms & Expertise
covaris


accessible for academic partners
 

Description

  • Mode-of-action: this device can be used for DNA fragmentation in a reproducible manner. It works through the ‘adaptive focused acoustics’ technology, referring to the use of a focused acoustic wave that leads to a mechanical energy inferred on the sample for shearing in an isothermal way.
  • Input: can be either purified DNA or in case of ChIP-seq samples purified and lysed nuclei
  • Output: reproducible DNA fragmentation of a uniform length of 200-300 bp ideal for library prep
  • In our research team this is a standard part of the procedure followed for ChIP-sequencing
  • The advantages compared to other sonicators is that a focused beam onto the sample is generated leading to minimal heating of the sample and very reproducible results

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Location

MRB1, UZ campus, Corneel Heymanslaan 10, 9000 Gent

Contact