Febe Roelandt
Doctoral fellow – Unit for Cellular and Molecular (Patho)physiology, Subunit Keratinocyte microenvironment lab, VIB-UGent Center for Inflammation Research
Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University
Principal investigator: prof. Esther Hoste (PhD)
Research focus
Squamous cell carcinomas (SCCs), including those derived from keratinocytes, are tumours with a high incidence and poor prognosis. Cytotoxic therapies, such as chemotherapy, are frequently included in SCC treatment and aim to induce extensive tumor cell death, including apoptosis, but many questions remain on how the death of one cell can induce clonal expansion and plasticity of survivor cells in its environment.
My central hypothesis is that endogenous levels of keratinocyte apoptosis control carcinogenesis. Understanding how cytotoxic cancer therapies, though effective at first, might aid tumour recurrence and progression is crucial for the design of more efficient treatments with fewer side effects.
Biography
- 2025-present: PhD Candidate at Ghent University, VIB-UGent
- 2023-2025: Master’s degree in biomedical sciences at Ghent University
- 2020-2023: Bachelor’s degree in biomedical sciences at Ghent University
Contact & links
- Lab address: VIB-UGent Center for Inflammation Research, Technologiepark 71, 9052 Gent-Zwijnaarde
- Keratinocyte Microenvironment Lab
- Febe Roelandt is interested to receive invitations for presentations or talks