prof. Vanessa Vermeirssen (PhD)

Technological advancements have led to a wealth of omics data in bulk, but also more and more at single cell level: genome, epigenome, transcriptome, proteome, metabolome, ... The capacity to integrate multi-omics data, to something more than the sum of the existing data, is key to elucidating the causes of complex diseases such as neuro-inflammatory diseases and cancer. Regulatory networks are a valuable tool to map systems-wide the relationships between DNA, RNA, proteins and metabolites and to understand the molecular mechanisms by which these biomolecules influence health and disease.
Our research focuses on acquiring a functional understanding of gene regulation and signaling through multi-omics data integration and regulatory network inference. To this end, we apply, benchmark and develop computational approaches involving statistics, bioinformatics and machine learning, as well as high-throughput experimental approaches. Our ultimate goal is to use this knowledge in the development of novel preventive or therapeutic strategies for successful personal healthcare. 
The CBIGR team has internationally recognized expertise in systems biology and bioinformatics, at the interface between biology and informatics. In cancer research, we aim to identify novel driver genes and pathways and characterize tumors and the interaction with their environment. At single cell level, we investigate regulatory heterogeneity and plasticity as responsible factors for drug escape and therapeutic failure. Current projects focus on cancers of the nervous system such as neuroblastoma and glioblastoma. In addition, we aim to unravel the molecular mechanisms of neuroinflammation in neuropsychiatric and neurodegenerative disorders and the gut-brain axis. We also study healthy neurodevelopment in comparison to these diseases.
 

Since October 2019, Vanessa Vermeirssen is head of the Laboratory for Computational Biology, Integromics and Gene Regulation (CBIGR) at the Department of Biomedical Molecular Biology (WE14 – Inflammation Research Centre) and Department of Biomolecular Medicine (GE31 – Center for Medical Genetics Ghent) and group leader at the Cancer Research Institute Ghent (CRIG) at UGent. She has internationally recognized expertise in systems biology and bioinformatics, more specifically in gene regulatory networks (GRNs), network inference and omics data integration. Her strength lies at the interface between biology and informatics. Experimentally, she has been developing high-throughput methods for mapping GRNs. Computationally, she has been instrumental in developing ensemble methodologies and benchmarking for bulk, single-sample and single-cell GRN inference and atlas-level and multi-omics data integration, including the use of regulatory genomics, epigenomics, transcriptomics, proteomics and metabolomics data. Currently, the work focusses on understanding gene regulation and signaling towards personalized medicine, mainly in disorders of the nervous system.
 

• Boris Vandemoortele - doctoral fellow
• Vittorio Zanzani - doctoral fellow
• Mirte De Temmerman - doctoral fellow
   

• Lab address CBIGR:  Zwijnaarde-Technologiepark 71, 9052 Ghent
• Lab address Medicine and Health Sciences: C. Heymanslaan 10, ingang 34 (2MRB1), 9000 Ghent
• ResearchGate 
• VIB-UGent Center for Inflammation Research 
• Center for Medical Genetics Ghent 
• X (former Twitter) 
• Vanessa Vermeirssen is interested to receive invitations for presentations or talks