In situ/point-of-care metabolomics: REIMS
Accessible to academic and industrial partners
Description
The Laboratory of Integrative Metabolomics (LIMET), led by Prof. Lynn Vanhaecke, has established expertise in developing and applying advanced mass spectrometry-based omics methods for small molecules, including (semi)quantitative, targeted, and untargeted approaches, to address research questions related to food safety, public health, and individual well-being.
The novel Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS) platform at LIMET is an advanced, ambient, high-throughput metabolomics and lipidomics fingerprinting system ideally suited for large-scale and/or clinical high-throughput untargeted applications. Unlike conventional hyphenated UHPLC-HRMS metabolomics and lipidomics platforms, LA-REIMS requires just 30 seconds per sample analysis with minimized sample preparation steps, drastically reducing analysis time and workload. At LIMET, validated LA-REIMS protocols have been developed for analyzing a wide variety of biological matrices, with a particular focus on biofluids such as blood, gastrointestinal contents, urine and saliva. Additionally, LIMET has developed and patented biofluid-specific nanofibrous membranes for metabolome sampling (MetaSAMP®s) directly compatible with LA-REIMS. These innovative samplers streamline biofluid sampling, provide optimal conditions for short-term sample storage, and enhance metabolome/lipidome coverage and reproducibility.
CRIG members and other interested researchers are welcome to inquire about sample requirements, collaborative opportunities, and analysis costs.
Location
Department of Veterinary Public Health and Food Safety, Lab of Integrative Metabolomics (LIMET), Salisburylaan 133, B-9820 Merelbeke