Doctoral fellow – Lab Normal and Malignant Hematopoiesis - Center for Medical Genetics (Faculty of Medicine and Health Science, UGent)
Principal Investigator: prof. Pieter Van Vlierberghe (PhD)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer. Currently, the standard treatment consists out an intense chemotherapy scheme. Even though the current treatment leads to high cure rates, it can also lead to long-term harmful side-effects, like infertility, loss of intellectual capacity and the development of secondary tumors. Furthermore, a significant number of T-ALL patients relapse and become refractory to intensive treatment, indicating the need for a less toxic and targeted therapy.
By using transgenic mice models, our laboratory wants to characterize new dependency genes and its downstream targets. So that we can have a better understanding of the pathways involved in T-ALL initiation and maintenance, and in that way we want to develop more targeted therapies.
Contact & links
- Lab address: Center for Medical Genetics Ghent, Lab of Normal and Malignant Hematopoiesis, Medical Research Building 2 (entrance 38 , 1st Floor, Room 110.007), Corneel Heymanslaan 10, 9000 Ghent, Belgium
- Center for Medical Genetics Ghent
- Lisa Demoen is interested to receive invitations for presentations or talks