FWO Doctoral Research Fellow - Unit for Structural Biology, VIB-UGent Centre for Inflammation Research and Department of Biochemistry and Microbiology, Faculty of Sciences, UGent
Principal investigator: prof. Savvas Savvides (PhD)
Although IL-1 was discovered more than forty years ago, several knowledge gaps remain within the current IL-1 family of cytokines and receptors. Many of the IL-1 cytokines have been extensively studied in the context of their pleiotropic tumor-promoting and/or tumor-suppressing effects. However, the molecular mechanisms surrounding the biological activity of the more recently identified members are still largely unknown. My research focuses on the structural and biophysical characterization of the known and possibly novel complexes between several IL-1 cytokines and receptors. This knowledge may give rise to interesting opportunities for existing and novel therapeutics targeting the IL-1 family in cancer and inflammatory diseases.