'Proteomimetic Polymers for Expanding the Druggable Proteome' - Seminar
'Proteomimetic Polymers for Expanding the Druggable Proteome', seminar by prof. Nathan Gianneschi.
In this presentation, we will describe the development of a new class of peptide polymer conjugate accessed via graft-through polymerization of peptidyl-monomers. The resulting dense array of peptides gives rise to key emergent properties that we exploit for the development of these materials as therapeutics: 1) Multivalency, 2) High molecular weight and tunable length scales, 3) Proteolytic/chemical stability and 4) Efficient intracellular penetration. We will highlight examples of the utility of this approach for engaging critical intracellular protein-protein interactions driving neurodegenerative disease and cancer.
Prof. Gianneschi (the Northwestern University) is currently Jacob & Rosaline Cohn Professor of Chemistry, Materials Science & Engineering, and Biomedical Engineering. The Gianneschi group takes an interdisciplinary approach to nanomaterials research with a focus on multifunctional materials with interests that include biomedical applications, programmed interactions with biomolecules and cells, and basic research into nanoscale materials design, synthesis and characterization.
- Host: prof. Bruno De Geest (PhD)
- When: August 29 2022 at 11:00
- Where: Leslokaal 0.1, S4 (Campus Sterre, Krijgslaan 281, 9000 Gent)
- Registration not required
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