dr. Sarah Deville (PhD)
Postdoctoral researcher - Laboratory of Experimental Cancer Research (Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, UGent)
Principal Investigator: prof. An Hendrix (PhD)
Extracellular vesicles (EVs) are important mediators in intercellular communication, in which they transfer lipids, membrane-associated and intraluminal proteins, and nucleic acids influencing various physiological and pathological processes. Quantification and characterization of EVs produced within the tumor microenvironment and understanding the underlying mechanisms are crucial to enable the application of EVs in a clinical setting. Clinical implementation of EV biomarkers is hampered by the lack of transparency in EV research and a standard methodology.
My research project is focused on the standardization of EV isolation and characterization methods.
- 'Comparison of extracellular vesicle isolation and storage methods using high-sensitivity flow cytometry'. PLoS One, 2021. (PMID 33539354)
- 'Time-resolved characterization of the mechanisms of toxicity induced by silica and amino-modified polystyrene on alveolar-like macrophages'. Arch. Toxicol., 2020. (PMID 31677074)
- 'Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes'. Cells, 2020. (PMID 32751082)
- 'Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles'. Cells, 2020. (PMID 32012900)
- 'Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles'. ACS Nano, 2019. (PMID 31525954)
- `Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques`. Biochimica et Biophysica Acta - Molecular Cell Research, 2014. (PMID: 24480461)