dr. Giel Tanghe (PhD)
Postdoctoral researcher, Lab for Molecular Signal Transduction in Inflammation, VIB - Center for Inflammation Research, Ghent University - Department for Biomedical Molecular Biology
Principal Investigator: prof. Rudi Beyaert (PhD)
My research focuses on IL-12 family cytokines, which possess cytokines with inflammatory as well as immunosuppressive properties, and how we can therapeutically target biological features of the IL-12 family in auto-immune diseases and immunomodulation in cancer.
- ‘Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation’. Journal of Experimental Medicine, 2020. (PMID: 32315377)
- ‘RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization’. Cellular and Molecular Life Sciences, 2018. (PMID: 29435596)
- ‘Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation’. Journal of Investigative Dermatology, 2017. (PMID: 29317263)