dr. Giel Tanghe (PhD)

CRIG member
Giel Tanghe

Postdoctoral researcher, Lab for Molecular Signal Transduction in Inflammation, VIB - Center for Inflammation Research, Ghent University - Department for Biomedical Molecular Biology
Principal Investigator: prof. Rudi Beyaert (PhD)


Research focus

My research focuses on IL-12 family cytokines, which possess cytokines with inflammatory as well as immunosuppressive properties, and how we can therapeutically target biological features of the IL-12 family in auto-immune diseases and immunomodulation in cancer.

Key publications

  • ‘Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation’. Journal of Experimental Medicine, 2020. (PMID: 32315377)
  • ‘RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization’. Cellular and Molecular Life Sciences, 2018. (PMID: 29435596)
  • ‘Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation’. Journal of Investigative Dermatology, 2017. (PMID: 29317263)

Contact & links

  • Lab address: VIB-UGent, Center for Inflammation Research, Technologiepark 71, 9052 Zwijnaarde - Gent
  • Beyaert Lab