dr. Benedicte Descamps (PhD)

CRIG member
Benedicte Descamps


Postdoctoral researcher - Infinity Lab (IMIT Ghent, MEDISIP, Faculty of Engineering and Architecture, UGent)
(PI: prof. Christian Vanhove)

 

Research focus

Over the last 100 years, biomedical imaging has developed from simple two-dimensional X-ray imaging into a compendium of powerful multi-dimensional imaging techniques and has progressed in four distinct ways: standardized protocol allowing quantitative imaging, innovations in medical devices, innovations in imaging analysis and innovations in imaging agents. Our research is directly related to these four domains, mainly in the field of small animal imaging.
 

Biography

Benedicte started her research career with an IWT grant in a collaboration between the  Neuroradiology dept. and the dept. of Neurology, investigating migraine without aura using functional MRI.  
Following her doctoral research, she switched from clinical to preclinical research at the Infinity lab. Next to small animal MRI, she also gained experience in other imaging modalities such as PET, SPECT, CT, US and optical imaging. She still has a special focus on MRI (cancer) applications. She is involved in study design, training, data acquisition and processing, writing ethical files (both for laboratory animals and human studies), etc.
 

Key publications

  • Hypoxia imaging with 18F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts. Radiat Oncol, 2018. (PMID: 29514673)
  • PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator. J Vis Exp, 2018. (PMID: 29364211)
  • Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation. Cancer Res, 2018. (PMID: 29217764)
  • Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA. J Control Release, 2017. (PMID: 28987878)
  • The VEGFR inhibitor cediranib improves the efficacy of fractionated radiotherapy in a colorectal cancer xenograft model. Eur Surg Res, 2017. (PMID: 28002822)
  • Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Discrimination between High-Grade Glioma and Radiation Necrosis in Rats. PLoS One, 2016. (PMID: 27559736)
  • Quantitative and Functional Requirements for Bioluminescent Cancer Models. In Vivo, 2016. (PMID: 26709122)
  • Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling. Oncotarget, 2015. (PMID: 26396176)
  • Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model. Oncotarget, 2015. (PMID: 26375674)
  • Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells. Biomaterials, 2015. (PMID: 25907048)

     

Contact & links

  • Innovative Flemish In-vivo Imaging Technology (INFINITY )
    INFINITY is a pre-clinical core imaging facility of Ghent University providing multi-modality small animal imaging services.
    Infinity Lab: entrance 21, Corneel Heymanslaan 10, Ghent
  • Medical Imaging and Signal Processing (MEDISIP )
    MEDISIP: entrance 36 (5th floor), Corneel Heymanslaan 10, Ghent
  • Innovative Molecular Imaging and Therapy (IMIT )
  • address: IBiTech; UZ campus entrance 36; Corneel Heymanslaan 10; 9000 Gent
  • dr. Descamps is interested to receive invitations for presentations or talks