dr. Alexander Schauwvlieghe (MD, PhD)

CRIG member
Alexander Schauwvlieghe


Clinical hematologist – Department of hematology (UZ Gent)
Board member of Dutch Belgian Mycoses Study Group
Member of EHA SWG – Infections in hematology
Principal Investigator: prof. Fritz Offner (MD, PhD)

 

Research focus

Patients with a hematological malignancy are prone for serious opportunistic infections like invasive fungal infections. The most frequent fungal infection in patients with leukemia is invasive aspergillosis. The mainstay of treatment are azoles but unfortunately resistance tot this antifungal medication is growing. In September 2020, I defended my PhD at Erasmus University, Rotterdam on risk factors, diagnosis and managemnt of azole-resistant aspergillosis. My research focuses now on the management of infectious complications in patients with hematological maligancy and on antimicrobial stewardship in patients with febrile neutropenia.
 

Biography

Alexander graduated in 2012 with great distinction at University Gent. Then, he started his Internal Medicine residency at AZ Sint-Jan Hospital in Bruges where he  fell in love with two disciplines: Haematology and Infectious Diseases. The second year of his Internal Medicine rotation was performed in Maria Middelares in Ghent. Following two years of Internal Medicine rotation, Alexander started his Haematology fellowship in Ghent University Hospital under the supervision of Prof. dr. F. Offner. During these years, he came in touch with dr. Bart Rijnders from Erasmus University Hospital in Rotterdam. Bart offered a PhD position on invasive fungal infections and after two years, Alexander left Ghent for a Dutch adventure crossing the Moerdijk in Rotterdam. Alexander combined his PhD work with finishing his Haematology fellowship in Rotterdam, under the supervision of Prof. Dr. J. Cornelissen and dr. P. te Boekhorst. In October 2019, Alexander registered as Internist-Haematologist. Following a 3.5-year experience in Rotterdam, a 7-month fellowship at University Hospitals Leuven followed. In 2019, he was awarded a place in the Clinical Research Training in Hematology (CRTH) program of the EHA (European Hematology Association). During his PhD, Alexander helped establishing the Dutch-Belgian Mycoses Study Group, which is an initiative to facilitate collaboration and research on invasive fungal infections by bringing Dutch and Belgian clinicians and researchers together with a common interest in these infections. Alexander defended his PhD at Erasmus University cum laude in September 2020 with the title: “risk factors, diagnosis and management of (azole-resistant) invasive aspergillosis.  Alexander is dedicated to continue research improving the care and outcome for patients with hematological conditions that have infectious complications. His future research will focus on de-escalation of antibiotic therapy for febrile neutropenia in patients with longstanding neutropenia and on the diagnosis and management of invasive fungal infections.
 

Key publications

  • Lateral flow assays for diagnosing invasive pulmonary aspergillosis in adult hematology patients: A comparative multicenter study. Med Mycol. 2020 Jun 1;58(4):444-452. doi: 10.1093/mmy/myz079.(PMID: 31290552)
  • High-dose posaconazole for azole-resistant aspergillosis and other difficult-to-treat mould infections.PMID: 31660650 PMCID: PMC7003872 DOI: 10.1111/myc.13028.
  • Influenza-Associated Pulmonary Aspergillosis: A Local or Global Lethal Combination? PMID: 31905234 PMCID: PMC7583400 DOI: 10.1093/cid/ciaa010
     

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