prof. Jan Philippé (MD, PhD)

CRIG group leader
Jan Philippé


Senior full professor (part-time)
Laboratory of Hematology, UZ Gent / UGent 
Faculty of Medicine and Health Sciences

 

Research focus

Our research is focused on leukemias, mainly optimization of diagnostic procedures (cytomorphology, immunophenotyping and molecular analyses), or optimization of follow-up procedures (ao. minimal residual disease monitoring). A main interest in the exploration of the leukemic stem cell and its role in acute myeloid leukemia and multi drug resistance.
 

Biography

As MD, I specialised in laboratory medicine in Ghent University and the free University of Brussels, supervising the laboratory of hematology. I have been teaching in Ghent University, and Rwanda National University. I have been board member of ISAC and president of the Belgian Society of Cytometry. I represent the Ghent University Hospital as affiliated center within EUROFLOW
 

Research team

  • prof dr Jan Philippé - PI, senior full professor (part-time)
  • dr. Mattias Hofmans (MD, PhD) - post-doctoral fellow
  • dr Karl Vandepoele - post-doctoral fellow
  • Barbara Denys - clinical biologist, doctoral fellow
  • Sofie De Sy - technician
  • Annick Willems - technician
     

Key publications

  • RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML. Blood 2018 (29669779)
  • The light Chain IgLV3-21 defines a new poor prognostic subgroup in chronic lymphocytic leukemia : results of a multicenter study. Clin Canc Res 2018 (29945996)
  • Clinical implications of measurable residual disease in AML : review of current evidence. Crit Rev Oncol Hemat 2019 (30661650)
  • TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment. Haematologica, 2019. (PMID: 31371409)
  • Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making. Br J Haematol, 2019 (PMID: 31617209)
  • Clinical significance of TARP expression in pediatric acute myeloid leukemia. HemaSphere, 2020 (PMID: 32309783)
  • CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out. Front Cell Dev Biol. 2020 (PMID: 33490078)
  • Deciphering molecular heterogeneity in pediatric AML using a cancer vs. normal transcriptomic approach. Pediatr. Res. 2020 (PMID 33069162)
  • Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia. Scientific Reports. 2021 (PMID: 33531590)
  • TARP as antigen in cancer immunotherapy. Cancer Immunology, Immunotherapy. 2021. (PMID: 34050774)
     

Contact & links

  • Laboratory of Hematology, Building 2P8 (entrance 22), Ghent University Hospital, Corneel Heymanslaan 10, B-9000 Ghent
  • EUROFLOW
  • LinkedIn
  • prof. Philippé is interested to receive invitations for presentations or talks